Multicenter Study

. 2021 Nov 2;144(18):1521-1523.

doi: 10.1161/CIRCULATIONAHA.121.055816. Epub 2021 Nov 1.

Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis

John R Power¹, Joachim Alexandre², Arrush Choudhary³, Benay Ozbay⁴, Salim Hayek⁵, Aarti Asnani³, Yuichi Tamura⁶, Mandar Aras⁷, Jennifer Cautela⁸, Franck Thuny⁸, Lauren Gilstrap⁹, Dimitri Arangalage¹⁰, Steven Ewer¹¹, Shi Huang¹², Anita Deswal¹³, Nicolas L Palaskas¹³, Daniel Finke^{14

15}, Lorenz Lehman¹⁴, Stephane Ederhy¹⁶, Javid Moslehi^#¹², Joe-Elie Salem^#¹⁶; International ICI-Myocarditis Registry†

Collaborators, Affiliations

Collaborators

International ICI-Myocarditis Registry†:
Baptiste Abbar, Yves Allenbach, Tariq U Azam, Alan Baik, Lauren A Baldassarre, Barouyr Baroudjian, Pennelope Blakley, Sergey Brodsky, Johnny Chahine, Wei-Ting Chan, Amy Copeland, Shanthini M Crusz, Grace Dy, Charlotte Fenioux, Kambiz Ghafourian, Arjun K Ghosh, Valérie Gounant, Avirup Guha, Manhal Habib, Osnat Itzhaki Ben Zadok, Lily Koo Lin, Michal Laufer-Perl, Carrie Lenneman, Darryl Leong, Matthew Martini, Tyler Meheghan, Elvire Mervoyer, Cecilia Monge, Ryota Morimoto, Anna Narezkina, Martin Nicol, Joseph Nowatzke, Olusola Ayodeji Orimoloye, Milan Patel, Daniel Perry, Nicolas Piriou, Lawrence Piro, Tyler Moran, Ben Stringer, Kazuko Tajiri, Pankit Vachhani, Ellen Warner, Marie-Claire Zimmer

Affiliations

¹ University of California San Diego Health (J.R.P.).
² University Caen Normandie, France (J.A.).
³ Beth Israel Deaconess Medical Center, Boston, MA (A.C., A.A.).
⁴ Basaksehir Cam and Sakura State Hospital, Istanbul, Turkey (B.O.).
⁵ Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor (S. Hayek).
⁶ International University of Health and Welfare Mita Hospital, Tokyo, Japan (Y.T.).
⁷ University of California, San Francisco (M.A.).
⁸ Assistance Publique-Hôpitaux de Marseille, Hôpital Nord, Marseille, France (J.C., F.T.).
⁹ Dartmouth Hitchcock Medical Center, Lebanon, NH (L.G.).
¹⁰ Hôpital Bichat, Paris, France (D.A.).
¹¹ University of Wisconsin Hospital, Madison (S. Ewer).
¹² Vanderbilt University Medical Center, Nashville, TN (S. Huang, J.M.).
¹³ University of Texas MD Anderson Cancer Center, Houston (A.D., N.L.P.).
¹⁴ University of Heidelberg, Germany (D.F., L.L.).
¹⁵ Assistance Publique-Hôpitaux de Paris, University of Paris, France (D.F.).
¹⁶ Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, France (S. Ederhy, J.-E.S.).

^# Contributed equally.

PMID: 34723640
PMCID: PMC8567307
DOI: 10.1161/CIRCULATIONAHA.121.055816

Multicenter Study

Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis

John R Power et al. Circulation. 2021.

. 2021 Nov 2;144(18):1521-1523.

doi: 10.1161/CIRCULATIONAHA.121.055816. Epub 2021 Nov 1.

Authors

Collaborators

International ICI-Myocarditis Registry†:
Baptiste Abbar, Yves Allenbach, Tariq U Azam, Alan Baik, Lauren A Baldassarre, Barouyr Baroudjian, Pennelope Blakley, Sergey Brodsky, Johnny Chahine, Wei-Ting Chan, Amy Copeland, Shanthini M Crusz, Grace Dy, Charlotte Fenioux, Kambiz Ghafourian, Arjun K Ghosh, Valérie Gounant, Avirup Guha, Manhal Habib, Osnat Itzhaki Ben Zadok, Lily Koo Lin, Michal Laufer-Perl, Carrie Lenneman, Darryl Leong, Matthew Martini, Tyler Meheghan, Elvire Mervoyer, Cecilia Monge, Ryota Morimoto, Anna Narezkina, Martin Nicol, Joseph Nowatzke, Olusola Ayodeji Orimoloye, Milan Patel, Daniel Perry, Nicolas Piriou, Lawrence Piro, Tyler Moran, Ben Stringer, Kazuko Tajiri, Pankit Vachhani, Ellen Warner, Marie-Claire Zimmer

Affiliations

¹ University of California San Diego Health (J.R.P.).
² University Caen Normandie, France (J.A.).
³ Beth Israel Deaconess Medical Center, Boston, MA (A.C., A.A.).
⁴ Basaksehir Cam and Sakura State Hospital, Istanbul, Turkey (B.O.).
⁵ Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor (S. Hayek).
⁶ International University of Health and Welfare Mita Hospital, Tokyo, Japan (Y.T.).
⁷ University of California, San Francisco (M.A.).
⁸ Assistance Publique-Hôpitaux de Marseille, Hôpital Nord, Marseille, France (J.C., F.T.).
⁹ Dartmouth Hitchcock Medical Center, Lebanon, NH (L.G.).
¹⁰ Hôpital Bichat, Paris, France (D.A.).
¹¹ University of Wisconsin Hospital, Madison (S. Ewer).
¹² Vanderbilt University Medical Center, Nashville, TN (S. Huang, J.M.).
¹³ University of Texas MD Anderson Cancer Center, Houston (A.D., N.L.P.).
¹⁴ University of Heidelberg, Germany (D.F., L.L.).
¹⁵ Assistance Publique-Hôpitaux de Paris, University of Paris, France (D.F.).
¹⁶ Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, France (S. Ederhy, J.-E.S.).

^# Contributed equally.

PMID: 34723640
PMCID: PMC8567307
DOI: 10.1161/CIRCULATIONAHA.121.055816

Erratum in

Correction to: Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis.
[No authors listed] [No authors listed] Circulation. 2021 Dec 7;144(23):e490. doi: 10.1161/CIR.0000000000001042. Epub 2021 Dec 6. Circulation. 2021. PMID: 34871113 No abstract available.

No abstract available

Keywords: cardio-oncology; electrophysiology; immunotherapy; myocarditis.

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References

1. Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, et al. Fulminant Myocarditis with Combination Immune Checkpoint Blockade. The New England journal of medicine. 2016;375:1749–1755. - PMC - PubMed
1. Zlotoff DA, Hassan MZO, Zafar A, Alvi RM, Awadalla M, Mahmood SS, Zhang L, Chen CL, Ederhy S, Barac A, et al. Electrocardiographic features of immune checkpoint inhibitor associated myocarditis. Journal for immunotherapy of cancer. 2021;9: e002007. - PMC - PubMed
1. Champion SN, Stone JR. Immune checkpoint inhibitor associated myocarditis occurs in both high-grade and low-grade forms. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2020;33:99–108. - PubMed
1. Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, et al. Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017;169:510–522. - PMC - PubMed
1. Wei SC, Meijers WC, Axelrod ML, Anang N-AAS, Screever EM, Wescott EC, Johnson DB, Whitley E, Lehmann L, Courand P-Y, et al. A genetic mouse model recapitulates immune checkpoint inhibitor-associated myocarditis and supports a mechanism-based therapeutic intervention. Cancer discovery. 2021; 614–625. - PMC - PubMed

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Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis

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Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis

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