High nevirapine levels in breast milk and consequences in HIV-infected child when initiated on antiretroviral therapy

Claire Pressiat¹, Thomas d'Aquin Toni², Jean-Marc Treluyer^{3

4}, Caroline Yonaba⁵, Désiré Lucien Dahourou^{6

7

8

9}, Karen Malateste⁹, Carole Seguin-Devaux¹⁰, Valériane Leroy^{11

12}, Déborah Hirt^{3

4

13

12}; MONOD ANRS Study Group

Affiliations

¹ Pharmacology Department, AP-HP, Hôpitaux Universitaires Henri Mondor, Paris Est-Créteil University, Créteil.
² Centre de Diagnostic et de Recherche sur le Sida (CeDReS), Centre Hospitalier Universitaire Treichville, Abidjan, Côte d'Ivoire.
³ Paris Descartes University, EA 7323.
⁴ Clinical Pharmacology Department, AP-HP, Paris Centre Hospital Group, Paris.
⁵ Pediatric Department, Centre Hospitalier Universitaire Yalgado Ouédraogo, Ouagadougou, Burkina Faso.
⁶ MONOD Project, ANRS 12206, Centre de Recherche Internationale pour la Santé, Ouagadougou.
⁷ Centre Muraz, Bobo-Dioulasso, Burkina Faso.
⁸ Institut de Recherche en Sciences de la Santé (IRSS), Ouagadougou.
⁹ University of Bordeaux, Inserm, Institut de Recherche pour le Développement (IRD), UMR 1219, Bordeaux.
¹⁰ Luxembourg Institute of Health, Luxembourg.
¹¹ CERPOP, Inserm, Université de Toulouse, Université Paul Sabatier, Toulouse.
¹² Valériane Leroy and Déborah Hirt have contributed equally to the work.
¹³ Inserm 1018 CESP, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Claire Pressiat et al. AIDS. 2021.

. 2021 Nov 15;35(14):2409-2410.

doi: 10.1097/QAD.0000000000003043.

¹ Pharmacology Department, AP-HP, Hôpitaux Universitaires Henri Mondor, Paris Est-Créteil University, Créteil.
² Centre de Diagnostic et de Recherche sur le Sida (CeDReS), Centre Hospitalier Universitaire Treichville, Abidjan, Côte d'Ivoire.
³ Paris Descartes University, EA 7323.
⁴ Clinical Pharmacology Department, AP-HP, Paris Centre Hospital Group, Paris.
⁵ Pediatric Department, Centre Hospitalier Universitaire Yalgado Ouédraogo, Ouagadougou, Burkina Faso.
⁶ MONOD Project, ANRS 12206, Centre de Recherche Internationale pour la Santé, Ouagadougou.
⁷ Centre Muraz, Bobo-Dioulasso, Burkina Faso.
⁸ Institut de Recherche en Sciences de la Santé (IRSS), Ouagadougou.
⁹ University of Bordeaux, Inserm, Institut de Recherche pour le Développement (IRD), UMR 1219, Bordeaux.
¹⁰ Luxembourg Institute of Health, Luxembourg.
¹¹ CERPOP, Inserm, Université de Toulouse, Université Paul Sabatier, Toulouse.
¹² Valériane Leroy and Déborah Hirt have contributed equally to the work.
¹³ Inserm 1018 CESP, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

No abstract available

References

1. Waitt CJ, Garner P, Bonnett LJ, Khoo SH, Else LJ. Is infant exposure to antiretroviral drugs during breastfeeding quantitatively important? A systematic review and meta-analysis of pharmacokinetic studies . J Antimicrob Chemother 2015; 70:1928–1941.
1. Foissac F, Bouazza N, Frange P, Blanche S, Faye A, Lachassinne E, et al. Evaluation of nevirapine dosing recommendations in HIV-infected children . Br J Clin Pharmacol 2013; 76:137–144.
1. De Vries-Sluijs TEMS, Dieleman JP, Arts D, Huitema ADR, Beijnen JH, Schutten M, et al. Low nevirapine plasma concentrations predict virological failure in an unselected HIV-1-infected population . Clin Pharmacokinet 2003; 42:599–605.
1. Corbett A, Kashuba A, Rezk N, et al. Antiretroviral drug concentrations in breast milk and breastfeeding infants. 15th Annual Conference on Retroviruses and Opportunistic Infections (CROI) 2/3/2008 to 2/6/2008; Boston, MA; Poster # 648.
1. Nevirapine. Drugs and Lactation Database (LactMed) [Internet]. Bethesda, MD: National Library of Medicine (US); 2006. http://www.ncbi.nlm.nih.gov/books/NBK501535/ . [Accessed 15 May 2021]