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. 2021 Dec 28;326(24):2524-2526.
doi: 10.1001/jama.2021.19996.

Durability of Antibody Levels After Vaccination With mRNA SARS-CoV-2 Vaccine in Individuals With or Without Prior Infection

Diana Zhong  1 , Shaoming Xiao  1 , Amanda K Debes  2 , Emily R Egbert  1 , Patrizio Caturegli  1 , Elizabeth Colantuoni  2 , Aaron M Milstone  1
Affiliations

Durability of Antibody Levels After Vaccination With mRNA SARS-CoV-2 Vaccine in Individuals With or Without Prior Infection

Diana Zhong et al. JAMA. .

Abstract

This study examines antibody durability in individuals who received an mRNA SARS-CoV-2 vaccine with prior SARS-CoV-2 infection vs those without infection.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Milstone reported receiving grant support from Merck outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Waning IgG Antibodies to SARS-CoV-2 After Vaccination in Health Care Workers With or Without Prior SARS-CoV-2 Infection
Prior SARS-CoV-2 infection was defined as positive SARS-CoV-2 polymerase chain reaction (PCR) test results prior to receipt of the first dose of the mRNA vaccine. The dotted lines represent the positive IgG threshold, at an antibody measurement of 1.23, the lines represent the unadjusted median antibody measurements as a function of days following mRNA vaccination, based on natural cubic splines (2 degrees of freedom) for each group, and shaded areas represent 95% CIs for the unadjusted median antibody measurements.
See this image and copyright information in PMC

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