Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Published Erratum
. 2022 Jan;143(1):119-121.
doi: 10.1007/s00401-021-02380-6.

Correction to: Apolipoprotein E regulates lipid metabolism and α‑synuclein pathology in human iPSC‑derived cerebral organoids

Jing Zhao  1   2 , Wenyan Lu  1   2 , Yingxue Ren  3 , Yuan Fu  1 , Yuka A Martens  1   2 , Francis Shue  1 , Mary D Davis  1   2 , Xue Wang  3 , Kai Chen  1 , Fuyao Li  1 , Chia-Chen Liu  1 , Neill R Graff-Radford  4 , Zbigniew K Wszolek  4 , Steven G Younkin  1 , David A Brafman  5 , Nilüfer Ertekin-Taner  1   4 , Yan W Asmann  3 , Dennis W Dickson  1 , Ziying Xu  6 , Meixia Pan  6 , Xianlin Han  6   7 , Takahisa Kanekiyo  1   2 , Guojun Bu  8   9
Affiliations
Published Erratum

Correction to: Apolipoprotein E regulates lipid metabolism and α‑synuclein pathology in human iPSC‑derived cerebral organoids

Jing Zhao et al. Acta Neuropathol. 2022 Jan.
No abstract available

PubMed Disclaimer

Figures

Fig. 4
Fig. 4
ApoE2 and apoE3, but not apoE4, partially rescue α-synuclein accumulation in apoE-deficient cerebral organoids. The APOE−/− iPSC-derived cerebral organoids at Day 90 were treated with conditioned media of immortalized astrocytes from APOE2-target replacement (TR), APOE3-TR, or APOE4-TR mice for 5 days. Conditioned media from Apoe-KO astrocytes were used as a control. a, A schematic workflow of the rescue experiments. b–i, Amounts of EEA1 (c), LAMP1 (d), GCase (e), LIMP1 (f), Plin2 (g), αSyn (h) and p-αSyn (i) in the RIPA fraction of the cerebral organoids after treatments were quantified by Western blotting. j–l, Amounts of total αSyn (k) and p-αSyn (l) in the SDS fraction of cerebral organoids after treatments were quantified by Western blotting. All data were normalized to β-actin levels. 3 cerebral organoids were pooled and analyzed as one sample. All data are expressed as mean ± SEM (n = 5 samples/each). Experiments were repeated in three independent differentiation batches. One-way ANOVA was performed to determine statistical significance. **p < 0.01, ****p < 0.0001, n.s., not significant
See this image and copyright information in PMC

Erratum for

Publication types

LinkOut - more resources