Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Nov 1;81(21):5396-5398.
doi: 10.1158/0008-5472.CAN-21-3200.

Estrogen Receptor: A Paradigm for Targeted Therapy

Senthil Damodaran  1 , Gabriel N Hortobagyi  2
Affiliations
Comment

Estrogen Receptor: A Paradigm for Targeted Therapy

Senthil Damodaran et al. Cancer Res. .

Abstract

Nearly two-thirds of breast cancers overexpress estrogen receptors, and endocrine therapy is considered the backbone of systemic therapy both in early and advanced settings. While this is now widely recognized in clinical practice, this is the culmination of outstanding contribution of many investigators and patients. Indubitably, estrogen receptor targeting has had the most impact among targeted therapies and has significantly affected patient survival. In this commentary, we revisit a landmark article published in Cancer Research in 1977 by Knight and colleagues, which laid the groundwork for the use of estrogen receptors in prognostication and adjuvant treatment selection, as well as some of the key breakthroughs in estrogen receptor biology that span more than a century.See related article by Knight and colleagues, Cancer Res 1977;37:4669-71.

PubMed Disclaimer

Comment on

References

    1. Yi M, Huo L, Koenig KB, Mittendorf EA, Meric-Bernstam F, Kuerer HM, et al. Which threshold for ER positivity? a retrospective study based on 9639 patients. Ann Oncol. 2014;25:1004–11.
    1. Jensen EV. On the mechanism of estrogen action. Perspect Biol Med. 1962;6:47–59.
    1. O'Malley BW, Sherman MR, Toft DO. Progesterone “receptors” in the cytoplasm and nucleus of chick oviduct target tissue. Proc Natl Acad Sci U S A. 1970;67:501–8.
    1. Jordan VC. Tamoxifen as the first targeted long-term adjuvant therapy for breast cancer. Endocr Relat Cancer. 2014;21:R235–46.
    1. Knight WA, Livingston RB, Gregory EJ, McGuire WL. Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer. Cancer Res. 1977;37:4669–71.

Substances

LinkOut - more resources