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Comment
. 2021 Nov 1;81(21):5399-5400.
doi: 10.1158/0008-5472.CAN-21-2708.

Macrophage Regulation of the Development of Castration-Resistant Prostate Cancer

Haider Al-Janabi  1 , Claire E Lewis  2
Affiliations
Comment

Macrophage Regulation of the Development of Castration-Resistant Prostate Cancer

Haider Al-Janabi et al. Cancer Res. .

Abstract

Androgen deprivation therapy (ADT) is the front-line treatment for early and metastatic prostate cancer, and the development of tumor resistance to it has major clinical consequences. Cancer cells start to proliferate and tumors begin to regrow, requiring the administration of more generic anticancer treatments like surgery, radiotherapy, and/or chemotherapy. Tumor-associated macrophages are known to drive tumor resistance to a number of anti-cancer therapies. El-Kenawi and colleagues now demonstrate a novel mechanism underpinning their ability to do so in prostate tumors during ADT. This involves the accumulation of cholesterol by macrophages in tumors and its transfer to cancer cells, where it acts as a precursor for androgen biosynthesis and results in the activation of androgen receptors.See related article by El-Kenawi and colleagues, p. 5477.

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References

    1. Gannon PO, Poisson AO, Delvoye N, Lapointe R, Mes-Masson A-M, Saad F. Characterization of the intra-prostatic immune cell infiltration in androgen-deprived prostate cancer patients. J Immunol Methods. 2009;348:9–17.
    1. Nonomura N, Takayama H, Nakayama M, Nakai Y, Kawashima A, Mukai M, et al. Infiltration of tumor-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer. BJU Int. 2011;107:1918–22.
    1. El-Kenawi A, Dominguez-Viqueira W, Liu M, Awasthi S, Abraham-Miranda J, Keske A, et al. Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer. Cancer Res. 2021;81:5477–90.
    1. Peltomaa AI, Raittinen P, Talala K, Taari K, Tammela TLJ, Auvinen A, et al. Prostate cancer prognosis after initiation of androgen deprivation therapy among statin users. a population-based cohort study. Prostate Cancer Prostatic Dis. 2021.
    1. Bousset L, Septier A, Bunay J, Voisin A, Guiton R, Damon-Soubeyrant C, et al. Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia. PLoS Biol. 2020;18:e3000948.

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