Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar;36(3):889-891.
doi: 10.1038/s41375-021-01456-2. Epub 2021 Nov 1.

Loss of Y and clonal hematopoiesis in blood-two sides of the same coin?

Viktor Ljungström #  1   2 , Jonas Mattisson #  1 , Jonatan Halvardson  1 , Tatjana Pandzic  1   2 , Hanna Davies  1 , Edyta Rychlicka-Buniowska  3 , Marcus Danielsson  1 , Paul Lacaze  4 , Lucia Cavelier  1   2 , Jan P Dumanski #  5   6 , Panagiotis Baliakas #  7   8 , Lars A Forsberg #  9   10
Affiliations

Loss of Y and clonal hematopoiesis in blood-two sides of the same coin?

Viktor Ljungström et al. Leukemia. 2022 Mar.
No abstract available

PubMed Disclaimer

Conflict of interest statement

JPD and LAF are cofounders and shareholders in Cray Innovation AB. PB has received honoraria from Abbvie, Gilead and Janssen and research funding from Gilead. All other authors declare no competing interest.

Figures

Fig. 1
Fig. 1. Co-occurrence of LOY and CHIP in monocytes of ageing men.
A Shows the level of LOY (%) in each monocyte sample (y-axis) plotted against the age in years of the sampled men. The color (red/gray) of each dot indicates whether a pathogenic CHIP mutation was detected in the sample, while shape (triangle/circle) denotes if the sample was classified as having LOY or not. The gene names and variant allele frequency (VAF) of the CHIP mutations are labeled next to the sample in which CHIP was present. The boxplot in B displays the relationship between different levels of LOY (%, y-axis) and the number of genes in which CHIP was detected (x-axis).
See this image and copyright information in PMC

References

    1. Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, et al. Age-related clonal hematopoiesis associated with adverse outcomes. N. Engl J Med. 2014;371:2488–98. doi: 10.1056/NEJMoa1408617. - DOI - PMC - PubMed
    1. Genovese G, Kahler AK, Handsaker RE, Lindberg J, Rose SA, Bakhoum SF, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N. Engl J Med. 2014;371:2477–87. doi: 10.1056/NEJMoa1409405. - DOI - PMC - PubMed
    1. Jaiswal S, Natarajan P, Silver AJ, Gibson CJ, Bick AG, Shvartz E, et al. Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease. N. Engl J Med. 2017;377:111–21. doi: 10.1056/NEJMoa1701719. - DOI - PMC - PubMed
    1. Forsberg LA, Rasi C, Malmqvist N, Davies H, Pasupulati S, Pakalapati G, et al. Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer. Nat Genet. 2014;46:624–8. doi: 10.1038/ng.2966. - DOI - PMC - PubMed
    1. Thompson DJ, Genovese G, Halvardson J, Ulirsch JC, Wright DJ, Terao C, et al. Genetic predisposition to mosaic Y chromosome loss in blood. Nature. 2019;575:652–7. doi: 10.1038/s41586-019-1765-3. - DOI - PMC - PubMed

Publication types

LinkOut - more resources