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Review
. 2021 Oct 23:2021:9234984.
doi: 10.1155/2021/9234984. eCollection 2021.

Detection of Herbal Combinations and Pharmacological Mechanisms of Clinical Prescriptions for Coronary Heart Disease Using Data Mining and Network Pharmacology

Siling Bi  1   2 , Liang Xu  2 , Shouqiang Chen  2 , Shuai Bu  2 , Yunsheng Xu  1   2
Affiliations
Review

Detection of Herbal Combinations and Pharmacological Mechanisms of Clinical Prescriptions for Coronary Heart Disease Using Data Mining and Network Pharmacology

Siling Bi et al. Evid Based Complement Alternat Med. .

Abstract

Though widely used in the treatment of coronary heart disease (CHD), the mechanism of traditional Chinese medicine (TCM) is still unclear because of its complex prescription rules. This study prospectively collected 715 prescriptions of TCM for the treatment of CHD. The characteristics of TCM in prescriptions were described and analyzed, and the rules of prescriptions were analyzed by using association rules. Frequency statistics showed that the high-frequency herbs with a frequency of more than 60% were Gan-cao, Huang-qi, Dang-gui, Chuan-xiong, Yan-hu-suo, and San-qi. The high-frequency herb combinations were summarized by using association rules. By using the method of the "Top N groups" to excavate the empirical prescriptions, the basic prescriptions for treating CHD were summarized. We named the intersection herbs of the basic prescriptions and the high frequency herbs as the core herbal prescription. To explore the possible mechanisms underlying the anti-CHD effect of the core herbal prescription, the bioactive components of core herbal prescription and their targets were screened out by using network pharmacology. Molecular docking was performed between the bioactive components and core targets. A total of 28 potential active ingredients and 5 core targets were identified for the treatment of CHD with core herbal prescription. The enrichment analysis results indicated that the mechanism of action mainly involved neuroactive ligand-receptor interaction and calcium signaling pathway. The commonly used herbal pairs for CHD with qi deficiency and blood stasis syndrome were Huang-qi and Dang-gui. The mechanism of action of common herbal pairs was also studied by network pharmacology. This study summarized the prescription rule of TCM in the treatment of CHD and may provide a new idea for the treatment of CHD.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Frequency distribution of the property, taste, and meridian distribution.
Figure 2
Figure 2
Common targets for drugs and diseases.
Figure 3
Figure 3
Herb ingredient-target-disease network. Yellow represents the disease, purple represents the herb, blue represents the active ingredient of the herb, and green represents the related targets of CHD.
Figure 4
Figure 4
Interaction diagram between herbs and potential targets of CHD.
Figure 5
Figure 5
PPI network diagram.
Figure 6
Figure 6
GO pathway analysis (the top 15).
Figure 7
Figure 7
KEGG pathway analysis (the top 15).
Figure 8
Figure 8
Binding energy of herbs and disease targets.
Figure 9
Figure 9
Molecular docking stereogram (a) and molecular docking molecular diagram (b).
Figure 10
Figure 10
Common targets for drug pairs and diseases.
Figure 11
Figure 11
PPI network diagram.
Figure 12
Figure 12
GO and KEGG pathway analysis (the top 15).
See this image and copyright information in PMC

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