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. 1987 Apr;23(4):455-8.
doi: 10.1111/j.1365-2125.1987.tb03075.x.

Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22

M Eichelbaum, M P Baur, H J Dengler, B O Osikowska-Evers, G Tieves, C Zekorn, C Rittner

Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22

M Eichelbaum et al. Br J Clin Pharmacol. 1987 Apr.

Abstract

In order to determine on which chromosome the gene controlling human cytochrome P-450 (debrisoquine/sparteine type) is located a linkage study of polymorphic sparteine oxidation (PSO) to various polymorphic markers was carried out. Positive information for linkage between PSO and the P1 blood group was obtained with a maximal LOD-score of LOD = 3.35 for both male and female recombination fraction estimates of theta m = theta f = 0.0. The P1 blood group has been recently mapped to the long arm of chromosome 22. Thus it can be concluded that the gene controlling human cytochrome P-450 (debrisoquine/sparteine) is situated on the long arm of chromosome 22 in close vicinity to P1.

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