Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Feb;57(2):583-585.
doi: 10.1002/ppul.25744. Epub 2021 Nov 2.

Severe COVID-19 evolving towards organizing pneumonia in a pediatric lung transplant recipient

David Drummond  1   2 , Caroline Thumerelle  3 , Antoine Roux  1   4 , Clémence Mordacq  3 , Pierre Frange  2   5 , Marianne Leruez-Ville  2   5 , Laure Gibault  6 , Laureline Berteloot  7 , Charlotte Roy  1   2 , Margaux Pontailler  2   8 , Vanessa Lopez  8 , Mehdi Oualha  2   9 , Marion Grimaud  9 , Laure de Saint Blanquat  9 , François Parquin  4 , Isabelle Sermet-Gaudelus  1   2   10
Affiliations
Comment

Severe COVID-19 evolving towards organizing pneumonia in a pediatric lung transplant recipient

David Drummond et al. Pediatr Pulmonol. 2022 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Pierre Frange is a consultant for and has received travel support from MSD France. Other authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Evolution of chest CT‐scans over time. (A) Month 9 (M9) postlung‐transplantation: normal aspect of the control CT scan. (B) M10, SARS‐Cov2 infection: onset of diffuse ground‐glass opacities predominantly in the posterior subpleural regions. (C) M10, 3 weeks after diagnosis of SARS‐Cov‐2 infection: partial regression of the anomalies with some scattered ground glass areas of lower density remaining. (D) M11, recurrence of the disease: new increase of ground glass opacities and development of bilateral subpleural consolidation areas. (E) M12, 1 month after the recurrence: progression of the consolidations towards retractile opacities associated with traction bronchiectasis and subpleural reticular images in favor of an evolution towards fibrosis. (F) M16, 4 months after the recurrence: improvement but persistence of subpleural reticular opacities and traction bronchiectasis. CT, computed tomography; SARS‐Cov2, severe acute respiratory syndrome coronavirus 2
Figure 2
Figure 2
Evolution of histopathology on transbronchial biopsies. (A) Month 11 (M11), recurrence of the disease: acute lung injury with fibrin deposits (star), interstitial inflammation, and pneumocytes hypertrophy in favor of organizing pneumonia (arrow) (hematoxylin eosin saffron stain, ×200 magnification). (B) M16, 4 months after the recurrence: fibrotic evolution with fibrotic plugs in alveoli (star) (hematoxylin eosin saffron stain, ×100 magnification) [Color figure can be viewed at wileyonlinelibrary.com]
See this image and copyright information in PMC

Comment on

  • COVID-19 in children treated with immunosuppressive medication for kidney diseases.
    Marlais M, Wlodkowski T, Al-Akash S, Ananin P, Bandi VK, Baudouin V, Boyer O, Vásquez L, Govindan S, Hooman N, Ijaz I, Loza R, Melgosa M, Pande N, Pape L, Saha A, Samsonov D, Schreuder MF, Sharma J, Siddiqui S, Sinha R, Stewart H, Tasic V, Tönshoff B, Twombley K, Upadhyay K, Vivarelli M, Weaver DJ, Woroniecki R, Schaefer F, Tullus K. Marlais M, et al. Arch Dis Child. 2021 Jul 19;106(8):798-801. doi: 10.1136/archdischild-2020-320616. Arch Dis Child. 2021. PMID: 33355203 Free PMC article.

References

    1. Messika J, Eloy P, Roux A, et al. COVID‐19 in lung transplant recipients. Transplantation. 2021;105(1):177‐186. - PubMed
    1. Marlais M, Wlodkowski T, Al‐Akash S, et al. COVID‐19 in children treated with immunosuppressive medication for kidney diseases. Arch Dis Child. 2020;106:798‐801. https://adc.bmj.com/content/early/2020/12/20/archdischild-2020-320616 - PMC - PubMed
    1. Hueso T, Pouderoux C, Péré H, et al. Convalescent plasma therapy for B‐cell‐depleted patients with protracted COVID‐19. Blood. 2020;136(20):2290‐2295. - PMC - PubMed
    1. Goss MB, Galván NTN, Ruan W, et al. The pediatric solid organ transplant experience with COVID‐19: an initial multi‐center, multi‐organ case series. Pediatr Transplant. 2021;25(3):e13868. - PMC - PubMed
    1. Pogatchnik BP, Swenson KE, Sharifi H, Bedi H, Berry GJ, Guo HH. Radiology–pathology correlation demonstrating organizing pneumonia in a patient who recovered from COVID‐19. Am J Respir Crit Care Med. 2020;202(4):598‐599. - PMC - PubMed