Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2022 Jan 1;45(1):119-126.
doi: 10.2337/dc21-1276.

Diabetic Peripheral Neuropathy and Urological Complications in Type 1 Diabetes: Findings From the Epidemiology of Diabetes Interventions and Complications Study

Rodica Pop-Busui  1 , Barbara H Braffett  2 , Hunter Wessells  3 , William H Herman  1 , Catherine L Martin  1 , Alan M Jacobson  4 , Aruna V Sarma  5
Affiliations
Clinical Trial

Diabetic Peripheral Neuropathy and Urological Complications in Type 1 Diabetes: Findings From the Epidemiology of Diabetes Interventions and Complications Study

Rodica Pop-Busui et al. Diabetes Care. .

Abstract

Objective: To evaluate associations between diabetic peripheral neuropathy (DPN) and urological complications in men and women with type 1 diabetes (T1D).

Research design and methods: Measurements of DPN at Epidemiology of Diabetes Intervention and Complications (EDIC) years 1, 14, and 17 and urological complications at EDIC year 17 were examined in 635 men (mean age 51.6 years, diabetes duration 29.5 years) and 371 women (mean age 50.6 years, diabetes duration 29.8 years) enrolled in the Diabetes Control and Complications Trial (DCCT)/EDIC study. DPN was defined by symptoms, signs, and abnormal electrophysiology or by abnormal Michigan Neuropathy Screening Instrument (MNSI) examination or questionnaire scores.

Results: Erectile dysfunction (ED) in combination with lower urinary tract symptoms (LUTS) was reported in 15% of men and female sexual dysfunction (FSD), LUTS, and urinary incontinence (UI) in 16% of women. Adjusted for age, drinking status, BMI, depression, DCCT/EDIC time-weighted mean HbA1c, microalbuminuria, hypertension, triglycerides, and statin medication use, the odds of reporting ED and LUTS versus no ED or LUTS at EDIC year 17 were 3.52 (95% CI 1.69, 7.31) times greater in men with confirmed DPN at EDIC year 13/14 compared to men without confirmed DPN. Compared to men without DPN, men with DPN based on abnormal MNSI examination or questionnaire scores had significantly higher odds of reporting ED and LUTS versus no ED or LUTS at EDIC year 17. There were no significant differences in DPN between women reporting both FSD and LUTS/UI compared with those without FSD or LUTS/UI at EDIC year 17.

Conclusions: In long-standing T1D, DPN is associated with the later development of urological complications in men.

Trial registration: ClinicalTrials.gov NCT00360815 NCT00360893.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flowchart of neurological and urological data collection in the DCCT/EDIC study.
See this image and copyright information in PMC

References

    1. Wessells H, Braffett BH, Holt SK, et al.; DCCT/EDIC Study Group . Burden of urological complications in men and women with long-standing type 1 diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort. Diabetes Care 2018;41:2170–2177 - PMC - PubMed
    1. Jacobson AM, Braffett BH, Cleary PA, et al.; DCCT/EDIC Research Group . Relationship of urologic complications with health-related quality of life and perceived value of health in men and women with type 1 diabetes: the Diabetes Control and Complications Trial/Epidemiology of Interventions and Complications (DCCT/EDIC) cohort. Diabetes Care 2015;38:1904–1912 - PMC - PubMed
    1. Pontiroli AE, Cortelazzi D, Morabito A. Female sexual dysfunction and diabetes: a systematic review and meta-analysis. J Sex Med 2013;10:1044–1051 - PubMed
    1. Wessells H. Insights and interventions in diabetes associated erectile dysfunction. J Urol 2013;190:15–16 - PubMed
    1. Wessells H, Penson DF, Cleary P, et al.; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group . Effect of intensive glycemic therapy on erectile function in men with type 1 diabetes. J Urol 2011;185:1828–1834 - PMC - PubMed

Publication types

MeSH terms

Associated data