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Review
. 2022 Jan;36(1):299-322.
doi: 10.1002/ptr.7312. Epub 2021 Nov 3.

Biological and pharmacological effects and nutritional impact of phytosterols: A comprehensive review

Elyas Nattagh-Eshtivani  1   2 , Hanieh Barghchi  2 , Naseh Pahlavani  3   4 , Mehdi Barati  5 , Yasaman Amiri  6 , Abdulmannan Fadel  7 , Maryam Khosravi  2 , Saeedeh Talebi  2 , Pishva Arzhang  8 , Rahele Ziaei  9 , Abed Ghavami  9
Affiliations
Review

Biological and pharmacological effects and nutritional impact of phytosterols: A comprehensive review

Elyas Nattagh-Eshtivani et al. Phytother Res. 2022 Jan.

Abstract

Phytosterols (PSs), classified into plant sterols and stanols, are bioactive compounds found in foods of plant origin. PSs have been proposed to exert a wide number of pharmacological properties, including the potential to reduce total and low-density lipoprotein (LDL) cholesterol levels and thereby decreasing the risk of cardiovascular diseases. Other health-promoting effects of PSs include anti-obesity, anti-diabetic, anti-microbial, anti-inflammatory, and immunomodulatory effects. Also, anticancer effects have been strongly suggested, as phytosterol-rich diets may reduce the risk of cancer by 20%. The aim of this review is to provide a general overview of the available evidence regarding the beneficial physiological and pharmacological activities of PSs, with special emphasis on their therapeutic potential for human health and safety. Also, we will explore the factors that influence the physiologic response to PSs.

Keywords: cancer; cardiovascular diseases; cholesterol-lowering; inflammation; phytosterols.

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References

REFERENCES

    1. Abumweis, S., Barake, R., & Jones, P. J. F. (2008). Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials. Food & Nutrition Research, 52(1), 1811.
    1. AbuMweis, S. S., Marinangeli, C. P., Frohlich, J., & Jones, P. J. (2014). Implementing phytosterols into medical practice as a cholesterol-lowering strategy: Overview of efficacy, effectiveness, and safety. The Canadian Journal of Cardiology, 30(10), 1225-1232. https://doi.org/10.1016/j.cjca.2014.04.022
    1. Acuff, R. V., Cai, D. J., Dong, Z.-P., & Bell, D. J. (2007). The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects. Lipids in Health and Disease, 6(1), 1-10.
    1. Alam, M. A., Uddin, R., Subhan, N., Rahman, M. M., Jain, P., & Reza, H. M. (2015). Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids, 2015, 496169. https://doi.org/10.1155/2015/496169
    1. Aldini, R., Micucci, M., Cevenini, M., Fato, R., Bergamini, C., Nanni, C., … Budriesi, R. (2014). Antiinflammatory effect of phytosterols in experimental murine colitis model: Prevention, induction, remission study. PLoS One, 9(9), e108112. https://doi.org/10.1371/journal.pone.0108112

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