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Meta-Analysis
. 2022 Jan;44(1):275-285.
doi: 10.1002/hed.26898. Epub 2021 Nov 3.

Salvage surgery for recurrent squamous cell carcinoma of the head and neck: Systematic review and meta-analysis

Mustafa G Bulbul  1   2 , Timothy J Genovese  2   3 , Kobina Hagan  2   4 , Soham Rege  2   5 , Ahad Qureshi  2   6 , Mark A Varvares  6   7
Affiliations
Meta-Analysis

Salvage surgery for recurrent squamous cell carcinoma of the head and neck: Systematic review and meta-analysis

Mustafa G Bulbul et al. Head Neck. 2022 Jan.

Abstract

The present study aims to estimate a pooled hazard ratio (HR) comparing overall survival (OS) for salvage surgery compared to nonsurgical management of recurrent head and neck squamous cell carcinoma (HNSCC). PubMed/MEDLINE and Embase-Ovid were searched on March 5, 2020, for English-language articles reporting survival for salvage surgery and nonsurgical management of recurrent HNSCC. Meta-analysis of HR estimates using random effects model was performed. Fifteen studies reported survival for salvage surgery and nonsurgical management of recurrence. Five-year OS ranged from 26% to 67% for the salvage surgery groups, compared to 0% to 32% for the nonsurgical management groups. Six studies reported HRs comparing salvage surgery to nonsurgical management; the pooled HR was 0.25 (95% CI [0.16, 0.38]; p < 0.0001). Selection for salvage surgery was associated with one quarter of the mortality rate associated with nonsurgical management in light of confounding factors including subsite and treatment intent.

Keywords: head and neck squamous cell carcinoma; meta-analysis; recurrent; salvage surgery; systematic review.

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References

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