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Comment
. 2021 Nov 2;33(11):2097-2099.
doi: 10.1016/j.cmet.2021.10.006.

Powering up microbiome-microglia interactions

Caoimhe M K Lynch  1 , Gerard Clarke  2 , John F Cryan  3
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Powering up microbiome-microglia interactions

Caoimhe M K Lynch et al. Cell Metab. .
Free article

Abstract

Despite extensive evidence implicating the microbiota in regulating the immune system, the precise mechanisms underlying microbial control of microglial maturation remain unclear. In a methodological tour de force, Erny et al. (2021) identify acetate as an essential microbiota-derived molecule driving microglial metabolic pathways and functions during healthy and diseased states.

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Conflict of interest statement

Declaration of interests J.F.C. has been an invited speaker at conferences organized by Mead Johnson, Alkermes, Janssen, Ordesa, and Yakult, and has received research funding from Mead Johnson, Cremo Nutricia, Pharmavite, Dupont, and 4D Pharma. G.C. has received honoraria from Janssen, Probi, and Apsen as an invited speaker; is in receipt of research funding from Pharmavite and Fonterra; and is a paid consultant for Yakult and Zentiva. This support neither influenced nor constrained the contents of this preview. C.M.K.L. declares no competing interests.

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