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Editorial
. 2021 Oct 26;12(22):2302-2304.
doi: 10.18632/oncotarget.28007.

Clinicopathological utility of human epidermal growth factor receptor 2 (HER2)-heterogeneity for next-generation treatments of triple-negative breast cancer

Editorial

Clinicopathological utility of human epidermal growth factor receptor 2 (HER2)-heterogeneity for next-generation treatments of triple-negative breast cancer

Sasagu Kurozumi et al. Oncotarget. .
No abstract available

Keywords: HER2 low; breast cancer; heterogeneity; triple negative.

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Conflict of interest statement

CONFLICTS OF INTEREST SK has received honoraria from Daiichi Sankyo Co. Ltd, Taiho Pharmaceutical Co. Ltd, Eli Lilly and Company, MSD K.K., AstraZeneca K.K., Chugai Pharmaceutical, and Novartis Japan.

Figures

Figure 1
Figure 1. Prospects on the changing of treatment-strategies based on HER2-expression for triple-negative cases.
In a present clinical practice, anti-HER2 treatments cannot be used for breast cancer with triple-negative type. Future translational research and clinical trial investigating the ability of new anti-HER2 antibody-drug conjugates (ADC) agents to HER2-heterogeneity type may lead to new treatment-strategies for triple-negative breast cancer.

References

    1. Slamon D, et al.. N Engl J Med. 2011; 365:1273–83. 10.1056/nejmoa0910383. - DOI - PMC - PubMed
    1. Geyer CE, et al.. N Engl J Med. 2006; 355:2733–43. 10.1056/nejmoa064320. - DOI - PubMed
    1. Verma S, et al.. N Engl J Med. 2012; 367:1783–91. 10.1056/nejmoa1209124. - DOI - PMC - PubMed
    1. Wolff AC, et al.. J Clin Oncol. 2018; 36:2105–22. 10.1200/jco.2018.77.8738. - DOI - PubMed
    1. Eiger D, et al.. Cancers (Basel). 2021; 13:1015. 10.3390/cancers13051015. - DOI - PMC - PubMed

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