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. 2021 Sep;9(18):1461.
doi: 10.21037/atm-21-4323.

Evaluation of reporting quality in clinical practice guidelines for acute myeloid leukemia using the RIGHT checklist

Ding Li  1 , Cheng Cheng  2 , Ziming Wang  3 , Yi Zhang  4 , Dongbei Li  2 , Wenping Song  1 , Baoxia He  1 , Xuan Wu  5 , Wenzhou Zhang  1
Affiliations

Evaluation of reporting quality in clinical practice guidelines for acute myeloid leukemia using the RIGHT checklist

Ding Li et al. Ann Transl Med. 2021 Sep.

Abstract

Background: Acute myeloid leukemia (AML) is an aggressive hematologic malignancy. Clinical practice guidelines (CPGs) on the management of AML have great value in clinical practice. However, the reporting quality of CPGs for AML has not yet been evaluated. This is the first study aiming to evaluate the reporting quality of the most recent AML CPGs published worldwide using the Reporting Items for Practice Guidelines in Healthcare (RIGHT) checklist.

Methods: We systematically searched PubMed, Chinese National Knowledge Infrastructure (CNKI), Wanfang, and Chinese Biomedical Literature (CBM) to extract CPGs for AML published between January 2016 and December 2020. Websites for guideline development organizations and medical associations were also searched. Two independent researchers assessed compliance of the guidelines to each of the 35 checklist items and summarized reporting rates for the 7 domains of the RIGHT checklist.

Results: We identified 16 guidelines, of which 3 (18.8%) were written in Chinese and 13 (81.3%) were written in English. The average overall reporting rate of the 16 guidelines was 52.9%, and only 7 CPGs (43.8%) had a reporting rate >50%. The average reporting rates of the 7 domains (basic information; background; evidence; recommendations; review and quality assurance; funding, declaration, and management of interests; and other information) were 79.2%, 62.5%, 38.8%, 53.6%, 21.9%, 32.8%, and 43.8%, respectively. For the 35 checklist items, the average reporting rate was 52.9%, and only 16 items had a reporting rate >50%, of which 5 items were reported by all the guidelines. There was 1 item which was not reported by any of the guidelines.

Conclusions: The reporting quality of recently published AML guidelines remains poor. While the recommendations of CPGs have great value in clinical practice, the reporting quality of CPGs for AML still needs to be improved.

Keywords: Acute myeloid leukemia; Reporting Items for Practice Guidelines in Healthcare (RIGHT); clinical practice guideline; improvement; reporting quality.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi.org/10.21037/atm-21-4323). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Flowchart of systematic search.
Figure 2
Figure 2
The mean reporting rate for each item of the RIGHT checklist.
Figure 3
Figure 3
The mean reporting rate for each domain of the RIGHT checklist.
See this image and copyright information in PMC

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