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. 2022 Aug;16(8):891-901.
doi: 10.1111/eip.13235. Epub 2021 Nov 3.

Randomized controlled trial of a mindfulness-based intervention in adolescents from the general population: The Mindfulteen neuroimaging study protocol

Camille Piguet  1   2 , Paul Klauser  3   4 , Zeynep Celen  2 , Ryan James Murray  2 , Mariana Magnus Smith  5 , Arnaud Merglen  5
Affiliations

Randomized controlled trial of a mindfulness-based intervention in adolescents from the general population: The Mindfulteen neuroimaging study protocol

Camille Piguet et al. Early Interv Psychiatry. 2022 Aug.

Abstract

Aim: Adolescence is a period of vulnerability to stress. Increased anxiety during this period has been associated with the later development of mental disorders, hence the growing interest for interventions that could decrease stress reactivity and improve cognitive control in adolescents. Mindfulness-based interventions have demonstrated their efficacy on stress reactivity and anxiety in adults, but evidence is lacking in youth.

Methods: The Mindfulteen Study is a 3-year longitudinal cohort with a nested randomized controlled trial examining the effectiveness of mindfulness-based interventions for adolescents. Young adolescents from the general population, aged between 13 and 15 years old, with no history of current mental health disorder (apart from past mood disorders or current anxiety disorders) are included and stratified into low or high anxiety based on trait anxiety scores before being randomized to early or late 8-week intervention groups. Primary outcomes are based on neuroimaging data (i.e., structural and functional measures in the cortico-limbic network) while secondary outcomes are psychological (i.e., anxiety and stress-associated dimensions) and biological (i.e., cortisol, inflammatory and redox markers). Assessments are performed at baseline, immediately after intervention or waiting time and after 18 months of intervention.

Conclusion: To the best of our knowledge, this is the first randomized controlled trail examining the effect of a mindfulness-based intervention in young adolescents from the general population based on the measurement and analyses of psychological, neuroimaging and biological data.

Keywords: adolescence; anxiety; inflammation; mindfulness; neuroimaging.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
(a) Study design. The V2 bis visit is proposed to participants on the late MBI group, after the intervention. (b) Nested randomized controlled trail. (c) Longitudinal cohort
FIGURE 2
FIGURE 2
Mindfulteen study visits. ICF: Informed consent form; ER task: emotion regulation task; STAI: Strai and Trait Anxiety Invetory; MBI: Mindfulness‐based intervention
See this image and copyright information in PMC

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