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. 2021 Oct;41(5):461-466.
doi: 10.14639/0392-100X-N1233.

Recurrence of benign paroxysmal positional vertigo: experience in 3042 patients

Roberto Teggi  1 , Riccardo Guidetti  2 , Omar Gatti  1 , Giorgio Guidetti  2
Affiliations

Recurrence of benign paroxysmal positional vertigo: experience in 3042 patients

Roberto Teggi et al. Acta Otorhinolaryngol Ital. 2021 Oct.

Abstract
in English, Italian

Objectives: Benign paroxysmal positional vertigo (BPPV) is a disorder of the inner ear with a high rate of recurrence. Vascular disorders, migraine and autoimmune disorders have been considered facilitating factors for relapsing episodes. Our aim was to assess the role of vascular disorders, migraine and anti-thyroid antibodies in patients with recurrences.

Methods: We retrospectively analysed records of 3042 patients treated for BPPV without other lifetime vertigo. Clinical data included previous vascular disorders of the central nervous system, heart disorders, migraine and recent head trauma. The presence of anti-thyroid autoantibodies was assessed in all patients.

Results: Mean age of the first BPPV was 52.8 ± 14.5 years; there were 2339 females (76.9%), while 2048 (67.3%) of patients presented recurrences within two years of follow-up. Previous disorders of the central nervous system, presence of anti-thyroid antibodies, head trauma and migraine showed an association with recurrences. Above all, in subjects having the first BPPV while aged between 40 and 60 years, anti-thyroid antibodies were predictive for recurrences.

Conclusions: Our data are consistent with the hypothesis that anti-thyroid autoantibodies may play a role in recurrences in subjects with initial manifestations between 40 and 60 years.

Le recidive della vertigine parossistica posizionale benigna: dati su un campione di 3042 soggetti.

Obiettivi: La vertigine parossistica posizionale benigna (VPPB) è una patologia con numerose recidive. Disordini vascolari, emicrania, traumi cranici e patologie autoimmuni sono stati considerati come fattori facilitanti. Scopo del nostro lavoro è stato stabilire il ruolo di tali fattori e la presenza di anticorpi anti tiroide come facilitanti le recidive.

Metodi: Retrospettivamente abbiamo analizzato i dati di 3042 soggetti trattati per VPPB con storia negativa per altri tipi di vertigine. I dati clinici includevano la presenza di disordini vascolari del sistema nervoso centrale, del miocardio, emicrania, traumi cranici recenti. Era inoltre stato chiesto di effettuare un dosaggio degli anticorpi anti tiroide.

Risultati: L’età media del primo episodio era di 52,8; i soggetti di sesso femminile erano 2339 (76,9%), mentre 2048 (67,3%) hanno presentato una ricorrenza nei 2 anni successivi. Precedenti vascolari del sistema nervoso centrale, positività per anticorpi anti tiroide (soprattutto nel soggetti tra 40 e 60 anni), traumi cranici ed emicrania erano correlati con recidive.

Conclusioni: I nostri dati sono compatibili con l’ipotesi che gli anticorpi anti tiroide possano giocare un ruolo favorente le recidive nei soggetti la cui prima manifestazione sia avvenuta tra i 40 e 60 anni.

Keywords: anti-thyroids autoantibodies; benign paroxysmal positional vertigo; bppv; migraine; vascular disorders of the central nervous system.

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Conflict of interest statement

Conflict of interest

The Authors declare no conflict of interest.

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