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. 2022 Mar;156(3):406-417.
doi: 10.1002/ijgo.14008. Epub 2021 Nov 13.

Systematic review of the safety, immunogenicity, and effectiveness of COVID-19 vaccines in pregnant and lactating individuals and their infants

Winnie Fu  1 , Brintha Sivajohan  2 , Elisabeth McClymont  3   4 , Arianne Albert  5 , Chelsea Elwood  3 , Gina Ogilvie  5   6   7 , Deborah Money  3   5
Affiliations

Systematic review of the safety, immunogenicity, and effectiveness of COVID-19 vaccines in pregnant and lactating individuals and their infants

Winnie Fu et al. Int J Gynaecol Obstet. 2022 Mar.

Abstract

Background: There is significant risk of complications and vulnerability to severe COVID-19 disease in pregnancy, yet hesitancy exists around COVID-19 vaccination during pregnancy and lactation.

Objective: To summarize the safety, immunogenicity, and effectiveness of COVID-19 vaccines in pregnancy and lactation.

Search strategy: A systematic search of MEDLINE, Embase, PubMed, medRxiv, and bioRxiv.

Selection criteria: Identified original studies published on pregnant and/or lactating individuals who received one or more doses of a COVID-19 vaccine.

Data collection and analysis: A descriptive summary organized by safety, immunogenicity, and effectiveness outcomes of COVID-19 vaccination in pregnancy and lactation.

Main results: In total, 23 studies were identified. Humoral response and functional immunity were interrogated and found. Increasing placental transfer ratios in cord blood were associated with increasing time from the first vaccine dose to delivery. Safety data indicated that pregnant and lactating populations experienced vaccine-related reactions at similar rates to the general population. No increased risk of adverse obstetrical or neonatal outcomes were reported. One study demonstrated that pregnant individuals were less likely to experience COVID-19 when vaccinated.

Conclusion: COVID-19 vaccination in pregnant and lactating individuals is immunogenic, does not cause significant vaccine-related adverse events or obstetrical and neonatal outcomes, and is effective in preventing COVID-19 disease.

Keywords: COVID-19; COVID-19 vaccines; SARS-CoV-2; breastfeeding; lactation; pregnancy.

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Conflict of interest statement

CE has received consulting fees from Gilead for work related to HIV, outside the submitted work. GO is a co‐investigator on an investigator‐led trial funded by Hologic Inc and Roche. DM has received funding in kind from Merck for unrelated vaccine projects. She has also received funding for unrelated clinical trials by GSK, Merck, Novartis, and Sanofi‐Pasteur. The other authors have no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Study selection flow diagram
See this image and copyright information in PMC

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