To grow and to stay, both controlled by RhoA: Opposing cellular effects on axon regeneration
- PMID: 34735789
- DOI: 10.1016/j.neuron.2021.10.009
To grow and to stay, both controlled by RhoA: Opposing cellular effects on axon regeneration
Abstract
In this issue of Neuron, Stern et al. (2021) demonstrate that cell-type-specific ablation of RhoA differentially affects axon regeneration outcomes in spinal cord injury models. Their findings highlight the importance of considering cell-type-specific strategies to promote axon regeneration.
Crown Copyright © 2021. Published by Elsevier Inc. All rights reserved.
Comment on
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RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury.Neuron. 2021 Nov 3;109(21):3436-3455.e9. doi: 10.1016/j.neuron.2021.08.014. Epub 2021 Sep 10. Neuron. 2021. PMID: 34508667