Can Preclinical Insights Give Us Hope for Effective Treatments for Epilepsy in 15q11-q13 Duplication Syndrome?

Affiliations

¹ Department of Pediatrics, Division of Neurology, Children's Hospital Los Angeles, Los Angeles, California; Departments of Pediatrics and Neurology, University of Southern California Keck School of Medicine, Los Angeles, California. Electronic address: sjeste@chla.usc.edu.
² Departments of Psychiatry and Pediatrics, Children's Hospital Los Angeles, Los Angeles, California; Departments of Psychiatry and Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California.

Comment

Shafali Jeste et al. Biol Psychiatry. 2021.

. 2021 Dec 1;90(11):735-737.

doi: 10.1016/j.biopsych.2021.09.021.

¹ Department of Pediatrics, Division of Neurology, Children's Hospital Los Angeles, Los Angeles, California; Departments of Pediatrics and Neurology, University of Southern California Keck School of Medicine, Los Angeles, California. Electronic address: sjeste@chla.usc.edu.
² Departments of Psychiatry and Pediatrics, Children's Hospital Los Angeles, Los Angeles, California; Departments of Psychiatry and Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California.

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Hyperexcitable Phenotypes in Induced Pluripotent Stem Cell-Derived Neurons From Patients With 15q11-q13 Duplication Syndrome, a Genetic Form of Autism.
Fink JJ, Schreiner JD, Bloom JE, James J, Baker DS, Robinson TM, Lieberman R, Loew LM, Chamberlain SJ, Levine ES. Fink JJ, et al. Biol Psychiatry. 2021 Dec 1;90(11):756-765. doi: 10.1016/j.biopsych.2021.07.018. Epub 2021 Jul 26. Biol Psychiatry. 2021. PMID: 34538422 Free PMC article.