Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov;96(11):2748-2752.
doi: 10.1016/j.mayocp.2021.07.005. Epub 2021 Jul 15.

TMPRSS2: An Equally Important Protease as ACE2 in the Pathogenicity of SARS-CoV-2 Infection

Malvinder S Parmar  1
Affiliations

TMPRSS2: An Equally Important Protease as ACE2 in the Pathogenicity of SARS-CoV-2 Infection

Malvinder S Parmar. Mayo Clin Proc. 2021 Nov.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic representation of transmembrane protease, serine 2: structure and domains. The numbers represent the amino acid sequence. COOH, C terminal; H, D, S, catalytic amino acid triad histidine, aspartic acid, and serine; LDLRA, low-density lipoprotein receptor class A; NH2, N terminal; SPCR, scavenger protein cysteine rich; TM, transmembrane domain.
Figure 2
Figure 2
Schematic (simplified) representation of transmembrane protease, serine 2 (TMPRSS2) acting as a key to the entry of the virus into the host cell. ACE2, angiotensin-converting enzyme 2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
See this image and copyright information in PMC

References

    1. Hoffmann M., Kleine-Weber H., Schroeder S., et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–280.e278. - PMC - PubMed
    1. Hou Y., Zhao J., Martin W., et al. New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis. BMC Med. 2020;18(1):216. - PMC - PubMed
    1. Sungnak W., Huang N., Becavin C., et al. HCA Lung Biological Network. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020;26(5):681–687. - PMC - PubMed
    1. Baughn L.B., Sharma N., Elhaik E., Sekulic A., Bryce A.H., Fonseca R. Targeting TMPRSS2 in SARS-CoV-2 infection. Mayo Clin Proc. 2020;95(9):1989–1999. - PMC - PubMed
    1. Paschkowsky S., Hsiao J.M., Young J.C., Munter L.M. The discovery of proteases and intramembrane proteolysis. Biochem Cell Biol. 2019;97(3):265–269. - PubMed

MeSH terms

Substances