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Comment
. 2021 Nov 9;118(45):e2117116118.
doi: 10.1073/pnas.2117116118.

A deep dive into local mRNA translation in neurons

Mauricio M Oliveira  1 , Eric Klann  2   3
Affiliations
Comment

A deep dive into local mRNA translation in neurons

Mauricio M Oliveira et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
The pipeline utilized to understand the differences between mRNAs translated in soma vs. dendrites. Glock et al. (2) used hippocampal slices to physically dissociate neuronal somata (green shade) and neuropil (yellow), a region that is enriched for neuronal dendrites. After doing both RNA-seq and Ribo-seq analysis for both regions, the authors defined neuropil- vs. soma-enriched mRNAs through differential expression analysis. This allowed the authors to observe structural differences in mRNAs that are preferentially translated in each compartment by determining differences in the coding sequence (CDS) and noncoding regions (UTRs) of these mRNAs.
See this image and copyright information in PMC

Comment on

  • The translatome of neuronal cell bodies, dendrites, and axons.
    Glock C, Biever A, Tushev G, Nassim-Assir B, Kao A, Bartnik I, Tom Dieck S, Schuman EM. Glock C, et al. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2113929118. doi: 10.1073/pnas.2113929118. Proc Natl Acad Sci U S A. 2021. PMID: 34670838 Free PMC article.

References

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