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. 2021 Oct 9:11:15003.
doi: 10.7189/jogh.11.15003. eCollection 2021.

Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade

Davies Adeloye  1 , Dhiraj Agarwal  2 , Peter J Barnes  3 , Marcel Bonay  4 , Job F van Boven  5 , Jamie Bryant  6 , Gaetano Caramori  7 , David Dockrell  8 , Anthony D'Urzo  9 , Magnus Ekström  10 , Gregory Erhabor  11 , Cristóbal Esteban  12 , Catherine M Greene  13 , John Hurst  14 , Sanjay Juvekar  2 , Ee Ming Khoo  15 , Fanny W Ko  16 , Brian Lipworth  17 , Jose L López-Campos  18 , Matthew Maddocks  19 , David M Mannino  20 , Fernando J Martinez  21 , Miguel A Martinez-Garcia  22 , Renae J McNamara  23 , Marc Miravitlles  24 , Hilary Pinnock  1 , Alison Pooler  25 , Jennifer K Quint  3 , Peter Schwarz  26 , George M Slavich  27 , Peige Song  28 , Andrew Tai  29 , Henrik Watz  30 , Jadwiga A Wedzicha  3 , Michelle C Williams  31 , Harry Campbell  1 , Aziz Sheikh  1 , Igor Rudan  1
Affiliations

Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade

Davies Adeloye et al. J Glob Health. .

Abstract

Background: The global prevalence of chronic obstructive pulmonary disease (COPD) has increased markedly in recent decades. Given the scarcity of resources available to address global health challenges and respiratory medicine being relatively under-invested in, it is important to define research priorities for COPD globally. In this paper, we aim to identify a ranked set of COPD research priorities that need to be addressed in the next 10 years to substantially reduce the global impact of COPD.

Methods: We adapted the Child Health and Nutrition Research Initiative (CHNRI) methodology to identify global COPD research priorities.

Results: 62 experts contributed 230 research ideas, which were scored by 34 researchers according to six pre-defined criteria: answerability, effectiveness, feasibility, deliverability, burden reduction, and equity. The top-ranked research priority was the need for new effective strategies to support smoking cessation. Of the top 20 overall research priorities, six were focused on feasible and cost-effective pulmonary rehabilitation delivery and access, particularly in primary/community care and low-resource settings. Three of the top 10 overall priorities called for research on improved screening and accurate diagnostic methods for COPD in low-resource primary care settings. Further ideas that drew support involved a better understanding of risk factors for COPD, development of effective training programmes for health workers and physicians in low resource settings, and evaluation of novel interventions to encourage physical activity.

Conclusions: The experts agreed that the most pressing feasible research questions to address in the next decade for COPD reduction were on prevention, diagnosis and rehabilitation of COPD, especially in low resource settings. The largest gains should be expected in low- and middle-income countries (LMIC) settings, as the large majority of COPD deaths occur in those settings. Research priorities identified by this systematic international process should inform and motivate policymakers, funders, and researchers to support and conduct research to reduce the global burden of COPD.

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Conflict of interest statement

Competing interests: The authors completed the ICMJE Unified Competing Interest form (available upon request from the corresponding author), and declare no conflicts of interest. Igor Rudan and Harry Campbell are the Co-Editor in Chief of the Journal of Global Health. To ensure that any possible conflict of interest relevant to the journal has been addressed, this article was reviewed according to best practice guidelines of international editorial organisations.

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