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. 1986:325:107-11.
doi: 10.1111/j.1651-2227.1986.tb10376.x.

Experimental research on IGF-1

A Skottner, L Fryklund, H A Hansson

Experimental research on IGF-1

A Skottner et al. Acta Paediatr Scand Suppl. 1986.

Abstract

IGF-1 has been produced by recombinant DNA technology; the host cell is a yeast. Studies in hypophysectomized rats show that IGF-1 has little growth promoting effect unless given by infusion at high doses, and priming with bovine growth hormone did not produce any potentiation. In vitro studies reveal that IGF-1 cross-reacts with the insulin receptor on adipose cells. Immunohistochemical studies have revealed high IGF-1 immunoreactivity in proliferating and differentiating cells in the testes, lymphoid organs and pancreatic islets and particularly in regenerating nerves. Local application of IGF-1 may stimulate regeneration in damaged peripheral nerves. Key words:

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