Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency

Aline Azabdaftari¹, Holm H Uhlig^{1

2

3}

Affiliations

¹ Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK.
² Department of Paediatrics, University of Oxford, Oxford, UK.
³ NIHR Oxford Biomedical Research Centre, Oxford, UK.

PMID: 34739344
DOI: 10.1126/sciimmunol.abm0293

Comment

Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency

Aline Azabdaftari et al. Sci Immunol. 2021.

. 2021 Nov 5;6(65):eabm0293.

doi: 10.1126/sciimmunol.abm0293. Epub 2021 Nov 5.

Authors

Aline Azabdaftari¹, Holm H Uhlig^{1

2

3}

Affiliations

¹ Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK.
² Department of Paediatrics, University of Oxford, Oxford, UK.
³ NIHR Oxford Biomedical Research Centre, Oxford, UK.

PMID: 34739344
DOI: 10.1126/sciimmunol.abm0293

Abstract

New data suggest how epithelial dysfunction and intestinal dysbiosis contribute to inflammatory bowel disease in patients and in models of XIAP deficiency (see the related Research Articles by Strigli et al. and Wahida et al.).

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XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.
Wahida A, Müller M, Hiergeist A, Popper B, Steiger K, Branca C, Tschurtschenthaler M, Engleitner T, Donakonda S, De Coninck J, Öllinger R, Pfautsch MK, Müller N, Silva M, Usluer S, Thiele Orberg E, Böttcher JP, Pfarr N, Anton M, Slotta-Huspenina JB, Nerlich AG, Madl T, Basic M, Bleich A, Berx G, Ruland J, Knolle PA, Rad R, Adolph TE, Vandenabeele P, Kanegane H, Gessner A, Jost PJ, Yabal M. Wahida A, et al. Sci Immunol. 2021 Nov 5;6(65):eabf7235. doi: 10.1126/sciimmunol.abf7235. Epub 2021 Nov 5. Sci Immunol. 2021. PMID: 34739338
Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation.
Strigli A, Gopalakrishnan S, Zeissig Y, Basic M, Wang J, Schwerd T, Doms S, Peuker K, Hartwig J, Harder J, Hönscheid P, Arnold P, Kurth T, Rost F, Petersen BS, Forster M, Franke A, Kelsen JR, Rohlfs M, Klein C, Muise AM, Warner N, Nambu R, Mayerle J, Török HP, Linkermann A, Muders MH, Baretton GB, Hampe J, Aust DE, Baines JF, Bleich A, Zeissig S. Strigli A, et al. Sci Immunol. 2021 Nov 5;6(65):eabf7473. doi: 10.1126/sciimmunol.abf7473. Epub 2021 Nov 5. Sci Immunol. 2021. PMID: 34739342

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Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency

Affiliations

Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

Supplementary concepts

Grants and funding

LinkOut - more resources

Full Text Sources