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. 2021 Nov 5;16(11):e0259545.
doi: 10.1371/journal.pone.0259545. eCollection 2021.

Libidibia ferrea (jucá) anti-inflammatory action: A systematic review of in vivo and in vitro studies

Nayanne C O S Almeida  1 , Felipe R P Silva  2 , Ana Lúcia B Carneiro  3 , Emerson S Lima  4 , José Fernando M Barcellos  5 , Silvania C Furtado  5
Affiliations

Libidibia ferrea (jucá) anti-inflammatory action: A systematic review of in vivo and in vitro studies

Nayanne C O S Almeida et al. PLoS One. .

Abstract

Libidibia ferrea (Mart. ex Tul.) L. P. Queiroz (jucá) is a plant extensively used in the Brazilian folk medicine for the treatment of the inflammatory process. Primary studies have focused on the verification of these biological activities, highlighting the role of this plant in inflammatory conditions. This systematic review aimed to critically establish which part of the plant and what type of plant extract present the highest evidence of anti-inflammatory activity as in vivo and in vitro experimental models. This study has followed the recommendations by PRISMA and was registered in the PROSPERO database under number CRD42020159934. The literature review was carried out in several medical and scientific databases (Google Scholar, LILACS, ProQuest, PubMed, ScienceDirect, Scopus and Web of Science) in studies published up to February 2020 and updated on March 2021. No language restriction was made to this search. Eligibility criteria were adopted instead. The risk of bias was evaluated through SYRCLE's RoB tool for the in vivo studies. 609 studies were initiated to identify the whole and the subsequent steps of screening. 13 studies remained in the results (10 in vivo and 3 in vitro). In most studies the risk of bias was low or unclear. The high risk of bias was related to the risk of attrition and reporting bias. The fruit and the aqueous extract were identified as the most used in the studies carried out on the qualitative analysis and the results of the in vivo and in vitro studies were conducive to the anti-inflammatory action, a meta-analysis could not be performed due to heterogeneity between studies and the potential risk of bias to estimate the side effects. Therefore, the implementation of in vivo studies following the international guidelines could collaborate with analyses of the anti-inflammatory effect of jucá.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram describing the study selections from literature searching.
*Update values.
Fig 2
Fig 2. Reporting quality in in vitro studies.
A. L. ferrea fruits quality reporting on in vitro study. B. L. ferrea leaves quality reporting on in vitro study. C and D. L. ferrea stem bark quality reporting on in vitro study. Grey: not determined; green bar: fulfilled; yellow bar: partially fulfilled; red bar: not fulfilled.
See this image and copyright information in PMC

References

    1. Di Stasi LC, Himura-Lima CA (2002) Caesalpinia ferrea. In: Plantas medicinais na Amazônia e na Mata Atlântica, 2 ed. rev. e ampl. Editora UNESP, São Paulo, ISBN 85-7139-411-3. pp. 279–280
    1. Stehmann JR, Faria FS, Bragioni T (2019) Pau-ferro. In: 50 árvores do Museu. Formato Editora, Belo Horizonte, ISBN 978-85-62164-13-2. pp. 90
    1. Maia-Silva C, Silva CI da, Hrncir M, Queiroz RT de, Imperatriz-Fonseca VL (2012) Jucazeiro. In: Guia de plantas visitadas por abelhas na caatinga, 1 ed. Editora Fundação Brasil Cidadão, Fortaleza, CE, ISBN 978-85-98564-05-0. pp. 43
    1. Nakamura ES, Kurosaki F, Arisawa M, Mukainaka T, Okuda M, Tokuda H, et al. (2002) Cancer chemopreventive effects of constituents of Caesalpinia ferrea and related compounds. Cancer Lett 177:119–124 doi: 10.1016/s0304-3835(01)00708-x - DOI - PubMed
    1. Ferreira MRA, Soares LAL (2015) Libidibia ferrea (Mart. ex Tul.) L. P. Queiroz: A review of the biological activities and phytochemical composition. J Med Plants Res 9:140–150. doi: 10.5897/JMPR2014.5706 - DOI

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