Can't touch this: Stromal-mediated ductal proliferation

Tara N McCray¹, Quinton Smith², Kelly R Stevens³

Affiliations

¹ Department of Bioengineering, University of Washington, Seattle, WA 98195, USA; Institute for Stem Cell and Regenerative Medicine, Seattle, WA 98195, USA.
² Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA 92697, USA; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: quintons@uci.edu.
³ Department of Bioengineering, University of Washington, Seattle, WA 98195, USA; Institute for Stem Cell and Regenerative Medicine, Seattle, WA 98195, USA; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA 98195, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA 98195, USA; Brotman Baty Institute, Seattle, WA 98195, USA. Electronic address: ksteve@uw.edu.

PMID: 34739828
DOI: 10.1016/j.stem.2021.10.006

Free article

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Can't touch this: Stromal-mediated ductal proliferation

Tara N McCray et al. Cell Stem Cell. 2021.

Free article

. 2021 Nov 4;28(11):1885-1887.

doi: 10.1016/j.stem.2021.10.006.

Authors

Tara N McCray¹, Quinton Smith², Kelly R Stevens³

Affiliations

¹ Department of Bioengineering, University of Washington, Seattle, WA 98195, USA; Institute for Stem Cell and Regenerative Medicine, Seattle, WA 98195, USA.
² Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA 92697, USA; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: quintons@uci.edu.
³ Department of Bioengineering, University of Washington, Seattle, WA 98195, USA; Institute for Stem Cell and Regenerative Medicine, Seattle, WA 98195, USA; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA 98195, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA 98195, USA; Brotman Baty Institute, Seattle, WA 98195, USA. Electronic address: ksteve@uw.edu.

PMID: 34739828
DOI: 10.1016/j.stem.2021.10.006

Abstract

Unraveling and replicating how cells communicate to regenerate organs remains one of the most compelling biological problems of our time. In this issue of Cell Stem Cell, Cordero-Espinoza et. al (2021) untangle how a subpopulation of liver mesenchymal cells residing adjacent to the bile ducts regulate biliary cell proliferation.

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Conflict of interest statement

Declaration of interests K.S. is a member of the Cell Stem Cell advisory board.

Comment on

Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation.
Cordero-Espinoza L, Dowbaj AM, Kohler TN, Strauss B, Sarlidou O, Belenguer G, Pacini C, Martins NP, Dobie R, Wilson-Kanamori JR, Butler R, Prior N, Serup P, Jug F, Henderson NC, Hollfelder F, Huch M. Cordero-Espinoza L, et al. Cell Stem Cell. 2021 Nov 4;28(11):1907-1921.e8. doi: 10.1016/j.stem.2021.07.002. Epub 2021 Aug 2. Cell Stem Cell. 2021. PMID: 34343491 Free PMC article.

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Can't touch this: Stromal-mediated ductal proliferation

Affiliations

Can't touch this: Stromal-mediated ductal proliferation

Authors

Affiliations

Abstract

Conflict of interest statement

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