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. 1987 Jun 15;929(1):114-6.
doi: 10.1016/0167-4889(87)90246-1.

Location of the phosphorylation site for casein kinase-2 within the amino acid sequence of ornithine decarboxylase

F Meggio, F Flamigni, C Guarnieri, L A Pinna

Location of the phosphorylation site for casein kinase-2 within the amino acid sequence of ornithine decarboxylase

F Meggio et al. Biochim Biophys Acta. .

Abstract

The sizes of the radiolabeled fragments obtained by CNBr and DMSO/HBr digestion of 32P-labeled ornithine decarboxylase phosphorylated by rat liver casein kinase TS (type-2) are consistent with the location of the phosphorylation site within the sequence(303-309) Ser-Asp-Asp-Glu-Asp-Glu-Ser. Parallel experiments with synthetic peptides rule out the suitability of Ser-309, as well as of other serines of ornithine decarboxylase having just two or three acidic residues close to their C terminal side. Ser-303 appears, therefore, to be the main if not the only target for casein kinase-2.

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