Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 Aug;22(3):347-357.
doi: 10.1007/s10238-021-00769-x. Epub 2021 Nov 6.

High levels of Von Willebrand factor markers in COVID-19: a systematic review and meta-analysis

Mehrdad Rostami  1 , Hassan Mansouritorghabeh  2   3 , Mohammad Parsa-Kondelaji  1
Affiliations
Meta-Analysis

High levels of Von Willebrand factor markers in COVID-19: a systematic review and meta-analysis

Mehrdad Rostami et al. Clin Exp Med. 2022 Aug.

Abstract

The SARS-CoV-2 virus has spread to all corners of the world. Thrombosis is the cause of organ failure and subsequent death in COVID-19. The pathophysiology of thrombosis in COVID-19 needs to be further explored to shed light on its downside. For this reason, this meta-analysis of Von Willebrand Factor profile (VWF: Ag, VWF: activity, VWF: RCo), ADAMTS-13, and factor VIII levels in COVID-19 was performed. To obtain data on the status of the aforementioned hemostatic factors, a systematic literature review and meta-analysis were performed on COVID-19. After reviewing the evaluation of 348 papers, 28 papers included in the meta-analysis, which was performed using STATA. The analysis showed an increase in VWF: Ag levels in COVID-19 patients. VWF: Ac was higher in all COVID-19 patients, while it was lower in the COVID-19 ICU patients. The pooled mean of VWF: RCO in all patients with COVID-19 was 307.94%. In subgroup analysis, VWF: RCO was significantly higher in ICU patients than in all COVID-19 patients. The pooled mean of ADAMTS-13 activity was 62.47%, and 58.42% in ICU patients. The pooled mean of factor VIII level was 275.8%, which was significantly higher in ICU patients with COVID-19 than all patients with COVID-19. Levels of VWF: Ag, VWF: activity, VWF: ristocetin, and factor VIII are increased in patients with COVID-19. The elevated levels in ICU patients with COVID-19 suggest that these markers may have prognostic value in determining the severity of COVID-19. New therapeutic programs can be developed as a result.

Keywords: ADAMTS-13; COVID-19; Factor VIII level; Thrombosis; VWF:AC; VWF:Ag; VWF:Co.

PubMed Disclaimer

Conflict of interest statement

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Figures

Fig. 1
Fig. 1
Flow diagram of selection process in the systematic Review
Fig. 2
Fig. 2
The forest plot of the mean in the VWF: Ag levels in COVID-19 patients
Fig. 3
Fig. 3
The forest plot of the mean in the VWF: Ac levels in COVID-19 patients
Fig. 4
Fig. 4
The forest plot of the mean in the VWF: RCO levels in COVID-19 patients
Fig. 5
Fig. 5
The forest plot of the mean in the ADAMTS-13 activity in COVID-19 patients
Fig. 6
Fig. 6
The forest plot of the mean in the F VIII levels in COVID-19 patients
Fig. 7
Fig. 7
Funnel plot of the VWF: Ag levels among patients with COVID-19
See this image and copyright information in PMC

References

    1. Ahmad M, Iqbal M, Drissi J, Hassan A. Modeling of Supply Chain Sustainability Enablers by Considering the Impact of COVID-19 on Developing Countries.
    1. WHO. WHO Coronavirus Disease (COVID-19) Dashboard 2021. Available at: https://covid19.who.int/. Accessed in August 29, 2021.
    1. Gao F, Zheng KI, Wang X-B, et al. Obesity is a risk factor for greater COVID-19 severity. Diabetes Care. 2020;43:e72–e74. doi: 10.2337/dc20-0682. - DOI - PubMed
    1. Cook T. The importance of hypertension as a risk factor for severe illness and mortality in COVID-19. Anaesthesia. 2020;75:976–977. doi: 10.1111/anae.15103. - DOI - PMC - PubMed
    1. Seiglie J, Platt J, Cromer SJ, et al. Diabetes as a risk factor for poor early outcomes in patients hospitalized with COVID-19. Diabetes Care. 2020;43:2938–2944. doi: 10.2337/dc20-1506. - DOI - PMC - PubMed