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. 2022 Mar 1;38(3):133-135.
doi: 10.1097/PEC.0000000000002564.

Recognizing and Managing Staphylococcal Scalded Skin Syndrome in the Emergency Department

Quoc-Bao D Nguyen, Mai-Anh N Vu  1 , Adelaide A Hebert
Affiliations

Recognizing and Managing Staphylococcal Scalded Skin Syndrome in the Emergency Department

Quoc-Bao D Nguyen et al. Pediatr Emerg Care. .

Abstract

Staphylococcal scalded skin syndrome is a superficial blistering disorder caused by exfoliative toxin-releasing strains of Staphylococcus aureus. Bacterial toxins are released hematogenously, and after a prodromal fever and exquisite tenderness of skin, patients present with tender erythroderma and flaccid bullae with subsequent superficial generalized exfoliation. The head-to-toe directed exfoliation lasts up to 10 to 14 days without scarring after proper treatment. Children younger than 6 years are predominantly affected because of their lack of toxin-neutralizing antibodies and the immature renal system's inability to excrete the causative exotoxins. The epidemiology, pathophysiology, and essential primary skin lesions used to diagnose staphylococcal scalded skin syndrome are summarized for the pediatric emergency medicine physician.

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Conflict of interest statement

Disclosure: The authors declare no conflict of interest.

References

    1. Mishra AK, Yadav P, Mishra A. A systemic review on staphylococcal scalded skin syndrome (SSSS): a rare and critical disease of neonates. Open Microbiol J . 2016;10:150–159.
    1. Patel GK, Finlay AY. Staphylococcal scalded skin syndrome: diagnosis and management. Am J Clin Dermatol . 2003;4:165–175. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12627992 . Accessed August 8, 2018.
    1. Staiman A, Hsu DY, Silverberg JI. Epidemiology of staphylococcal scalded skin syndrome in U.S. children. Br J Dermatol . 2018;178:704–708.
    1. Li MY, Hua Y, Wei GH, et al. Staphylococcal scalded skin syndrome in neonates: an 8-year retrospective study in a single institution. Pediatr Dermatol . 2014;31:43–47.
    1. Handler MZ, Schwartz RA. Staphylococcal scalded skin syndrome: diagnosis and management in children and adults. J Eur Acad Dermatol Venereol . 2014;28:1418–1423.

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