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. 2021;38(3):e2021022.
doi: 10.36141/svdld.v38i3.10883. Epub 2021 Sep 30.

Leukocytoclastic vasculitis associated with multifocal sensory neuropathy responsive to intravenous immunoglobulins: a case report

Martina Ferranti  1 , Elena Cama  1 , Mario Cacciavillani  2 , Franco Schiavon  3 , Mara Felicetti  3 , Chiara Briani  4 , Mauro Alaibac  1   2   3   4
Affiliations

Leukocytoclastic vasculitis associated with multifocal sensory neuropathy responsive to intravenous immunoglobulins: a case report

Martina Ferranti et al. Sarcoidosis Vasc Diffuse Lung Dis. 2021.

Abstract

Leukocytoclastic vasculitis (LCV) is a common form of small-vessel vasculitis, which commonly presents as palpable purpura or petechiae, caused by deposition of circulating immune complexes on vessels walls that attracts granulocytes which damage the vascular endothelium and leading to erythrocytes extravasation. The skin is the most commonly involved organ, but also renal, gastrointestinal, pulmonary, cardiovascular and neurological systems may be affected. Skin lesions may be the initial signs of systemic vasculitis. Systemic symptoms may be present, such us fever, myalgia, abdominal pain and arthralgia. The presence of neuropathy/mononeuritis multiplex is expression of severe vasculitic involvement. Herein, we describe the case of a patient with leucocytoclastic vasculitis associated to sensitive neuropathy, responsive to intravenous immunoglobulins (IVIg) therapy, after the failure of classic systemic treatments.

Keywords: Intravenous immunoglobulins; Leukocytoclastic vasculitis; Sensory neuropathy.

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article.

Figures

Figure 1.
Figure 1.
Necrotic lesions on the right pretibial region.
Figure 2.
Figure 2.
Histologic findings: leukocytoclastic vasculitis with perivascular inflammatory infiltrate, endoluminal thrombosis and thickening of the blood vessels wall.
Figure 3.
Figure 3.
Necrotic hemorrhagic evolution of the lesions of lower limbs.
Figure 4.
Figure 4.
Improvement of the skin lesions after a single infusion of IVIg (2 g/kg).
See this image and copyright information in PMC

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