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Review
. 2022 Jan:73:102988.
doi: 10.1016/j.amsu.2021.102988. Epub 2021 Oct 30.

Vaccine-induced thrombotic thrombocytopenia following coronavirus vaccine: A narrative review

Syed Hassan Ahmed  1 , Taha Gul Shaikh  1 , Summaiyya Waseem  1 , Nashwa Abdul Qadir  1 , Zohaib Yousaf  2 , Irfan Ullah  3
Affiliations
Review

Vaccine-induced thrombotic thrombocytopenia following coronavirus vaccine: A narrative review

Syed Hassan Ahmed et al. Ann Med Surg (Lond). 2022 Jan.

Abstract

The novel coronavirus pandemic has taken a toll on the global healthcare systems and economy. Safety precautions, along with vaccination, are the most effective preventive measures. The global vaccination program against COVID-19 has dramatically reduced the number of deaths and cases. However, the incidence of thrombotic events and thrombocytopenia post-COVID-19 vaccination known as vaccine-induced thrombotic thrombocytopenia has raised safety concerns. This has led to an element of vaccine hesitancy. The exact mechanism for vaccine-induced thrombotic thrombocytopenia is unknown. Although the incidence of thrombosis associated with COVID-19 vaccination is low, it still requires attention, especially in older people, smokers, and people with preexisting comorbidities. This study aims to review the pathophysiology, diagnosis, and management of vaccine-induced thrombotic thrombocytopenia, to provide a concise and comprehensive update.

Keywords: COVID-19; COVID-19 vaccine; Thrombotic thrombocytopenia; VITT; Vaccine induced immune thrombotic thrombocytopenia; Vaccine induced thrombotic thrombocytopenia.

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Conflict of interest statement

The authors declare that there is no conflict of interests.

Figures

Fig. 1
Fig. 1
Prisma flowchart.
Fig. 2
Fig. 2
Geographical distribution of the reported cases.
See this image and copyright information in PMC

References

    1. Mahase E. Covid-19: WHO declares pandemic because of "alarming levels" of spread, severity, and inaction. BMJ. 2020;368:m1036. doi: 10.1136/bmj.m1036. Published 2020 Mar 12. - DOI - PubMed
    1. Myanmar WHO coronavirus disease (COVID-19) dashboard with vaccination data | WHO coronavirus (COVID-19) dashboard with vaccination data. https://covid19.who.int/region/searo/country/mm n.d.
    1. FDA takes key action in fight against COVID-19 By issuing emergency use authorization for first COVID-19 vaccine | FDA. https://www.fda.gov/news-events/press-announcements/fda-takes-key-action... (n.d.)
    1. Castells M.C., Phillips E.J. Maintaining safety with SARS-CoV-2 vaccines. N. Engl. J. Med. 2021;384(7):643–649. doi: 10.1056/NEJMra2035343. - DOI - PMC - PubMed
    1. Vaccine efficacy, effectiveness and protection. https://www.who.int/news-room/feature-stories/detail/vaccine-efficacy-ef... n.d.