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. 2022 Jan-Feb;12(1):22-26.
doi: 10.1016/j.jobcr.2021.09.020. Epub 2021 Oct 5.

A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health

Sneha Singh  1 , Anootpal Gogoi  2 , Ashish Kumar  3 , Eesha  4 , Rinku Jagnade  5 , Gaurav Jain  6 , Sanjay Rastogi  7 , Sanjay Dutta  8
Affiliations

A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health

Sneha Singh et al. J Oral Biol Craniofac Res. 2022 Jan-Feb.

Abstract

Background/purpose: This research aimed to compare the effects of systemically prescribed Lycopene as a monotherapy and as an alternative to scaling and root planing in patients with chronic gingivitis.

Materials and methods: The participants were randomly assigned to one of two treatment groups: the experimental group (n = 50), which received 10 mg of Lycopene a day for two weeks, or the control group (n = 50) received a placebo for two weeks. For each category, quadrant distribution was randomized, with two quadrants receiving oral prophylaxis (OP) and two quadrants receiving no care (non-OP). At baseline, 1st, and 2nd weeks, the sulcus bleeding index, plaque index, gingival index, and salivary uric acid level were measured.

Results: All clinical criteria, including SBI, PI, GI, and salivary uric acid levels, showed a statistically significant decline in all patient types. Both clinical parameters were significantly reduced (p < 0.001) in the OP-lycopene group relative to the non-OP-placebo group and non-OP lycopene group (p < 0.05). The PI value in the OP-lycopene group was statistically significantly lower (p < 0.001) than in the non-OP-placebo group; there was no statistically significant difference in the other groups. Salivary uric acid levels in the OP- and non-OP- lycopene groups were significantly lower (p < 0.001) than in the non-OP-placebo population.

Conclusion: Based on the findings of this study, Lycopene seems to have a bright future as a treatment option for plaque-induced generalized chronic marginal gingivitis. More research with a broad sample size and multicentre trials is required.

Clinical relevance: The article reveals the positive relationship between Lycopene and gingivitis. The analysis shows that a combination of systemically administered Lycopene with oral prophylaxis can be a valuable tool in treating chronic gingivitis and controlling respiratory oxidative stress.

Keywords: Chronic gingivitis; Lycopene; Oral prophylaxis; Placebo; ROS.

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Conflict of interest statement

The authors have no conflicts of interest relevant to this article.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Flow diagram for patient recruitment and follow-up.
See this image and copyright information in PMC

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