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Case Reports
. 2021 Oct 22:8:675030.
doi: 10.3389/fmed.2021.675030. eCollection 2021.

Case Report: Metagenomics Next-Generation Sequencing Can Be Performed for the Diagnosis of Disseminated Mucormycosis

Yi Sun  1   2 , HuiLing Li  3 , JiaJun Chen  4 , ZhongHui Ma  2   5 , Pin Han  1   2 , YuChen Liu  1   2 , Jing Wen  1   2 , Fang Ren  1 , XiaoXu Ma  3
Affiliations
Case Reports

Case Report: Metagenomics Next-Generation Sequencing Can Be Performed for the Diagnosis of Disseminated Mucormycosis

Yi Sun et al. Front Med (Lausanne). .

Abstract

Mucormycosis is an infection caused by a group of filamentous molds with in the order Mucorales. In developing countries, most cases of mucormycosis occur in persons with poorly controlled diabetes mellitus or subjects with normal post-traumatic immune function. Mucormycosis exhibits a marked propensity for invading blood vessels. The mortality rate of invasive mucormycosis is very high (>30-50%), and 90% of mortality is related to disseminated diseases. We report a 62-year-old man with underlying diseases, such as diabetes and psoriatic arthritis, with a history of trauma before admission. Chest CT showed multiple cavities. Based on the suspected clinical manifestation of mucormycosis infection, the patient received a microbiological culture of bronchoalveolar lavage fluid, and metagenomics next generation sequencing (mNGS) was performed. The results suggested Klebsiella pneumoniae infection. However, Rhizopus microsporus strains were shown by the mNGS of transpulmonary puncture tissue. Therefore, we report a case in which rare pathogens are identified by mNGS.

Keywords: alveolar lavage; diabetes; metagenomics next generation; mucormycosis; pulmonary cavity.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Chest CT upon admission to the hospital.
Figure 2
Figure 2
Chest CT 10 days after transfer.
Figure 3
Figure 3
Diagnosis and treatment of the patient.
See this image and copyright information in PMC

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