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. 2021 Sep;6(3):262-267.
doi: 10.1177/23969873211040990. Epub 2021 Aug 31.

Estonian young stroke registry: High burden of risk factors and high prevalence of cardiomebolic and large-artery stroke

Riina Vibo  1 , Siim Schneider  1 , Liisa Kõrv  1 , Sandra Mallene  1 , Liisi-Anette Torop  1 , Janika Kõrv  1
Affiliations

Estonian young stroke registry: High burden of risk factors and high prevalence of cardiomebolic and large-artery stroke

Riina Vibo et al. Eur Stroke J. 2021 Sep.

Erratum in

Abstract

Background and aims: The aim of the present study was to assess the risk factor burden and stroke etiology of young stroke patients in Estonia and to compare the results with similar cohorts from other countries.

Methods: This study includes ischemic stroke patients aged 18-54 years from the prospective Estonian Young Stroke Registry between 2013 and 2020. All patients were managed in a stroke unit following a prespecified detailed protocol. Data on stroke risk factors, etiology, and stroke severity were analyzed.

Results: A total of 437 patients (mean age 44.7 ± 8.3 years; 62% males) were included in the registry during the 8-year study period. A total of 50.2% of patients had ≥ 3 well-documented risk factors (higher for men: odds ratio (OR) 3.8; 95% cardiac index confidence interval (CI) 1.8-8.3; p < .001) and 6.2% of patients had ≥ 3 less well-documented risk factors. While 42% of patients had undetermined cause of stroke (34% of them cryptogenic), the second most frequent etiologies were large-artery atherosclerosis and cardioembolism (both 19%). 60 percent of cardioembolic strokes were due to high-risk causes. Large-artery atherosclerosis was more prevalent in men (OR 1.8; 95% CI 1-3.3; p = .05) and among older patients (OR 6.2; 95% CI 1.8-21.4; p = .008). The median National Institutes of Health Stroke Scale score on admission was 3 (interquartile ranges 2-6), stroke was more severe in men (p = .05).

Conclusions: Our study revealed that young patients with stroke in Estonia have higher burden of well-documented risk factors, higher prevalence of high-risk cardioembolic causes and higher prevalence of large-artery stroke compared to other young stroke cohorts.

Keywords: risk factors; stroke etiology; trial of org 10,172 in acute stroke treatment classification; young stroke.

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Conflict of interest statement

Declaration of conflicting interest: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
The burden on well-documented (a) and less well-documented (b) risk factors according to sex and age-group.
See this image and copyright information in PMC

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