Plk1 in Asthma: Ready for Primetime?

John Kit Chung Tam^{1

2}, Thai Tran^{1

3}

Affiliations

¹ Yong Loo Lin School of Medicine National University of Singapore Singapore.
² Department of Cardiac, Thoracic, and Vascular Surgery National University Heart Centre Singapore.
³ Infectious Disease Translational Research Program National University of Singapore Singapore.

Editorial

John Kit Chung Tam et al. Am J Respir Cell Mol Biol. 2022 Feb.

. 2022 Feb;66(2):124-125.

doi: 10.1165/rcmb.2021-0425ED.

John Kit Chung Tam^{1

2}, Thai Tran^{1

3}

¹ Yong Loo Lin School of Medicine National University of Singapore Singapore.
² Department of Cardiac, Thoracic, and Vascular Surgery National University Heart Centre Singapore.
³ Infectious Disease Translational Research Program National University of Singapore Singapore.

No abstract available

Comment on

Plk1 Regulates Caspase-9 Phosphorylation at Ser-196 and Apoptosis of Human Airway Smooth Muscle Cells.
Liao G, Wang R, Tang DD. Liao G, et al. Am J Respir Cell Mol Biol. 2022 Feb;66(2):223-234. doi: 10.1165/rcmb.2021-0192OC. Am J Respir Cell Mol Biol. 2022. PMID: 34705620 Free PMC article.

1. Golsteyn RM, Lane HA, Mundt KE, Arnaud L, Nigg EA. The family of polo-like kinases. Prog Cell Cycle Res . 1996;2:107–114. - PubMed
1. Strebhardt K, Ullrich A. Targeting polo-like kinase 1 for cancer therapy. Nat Rev Cancer . 2006;6:321–330. - PubMed
1. Stewart AG, Fernandes D, Tomlinson PR. The effect of glucocorticoids on proliferation of human cultured airway smooth muscle. Br J Pharmacol . 1995;116:3219–3226. - PMC - PubMed
1. Halayko AJ, Tran T, Ji SY, Yamasaki A, Gosens R. Airway smooth muscle phenotype and function: interactions with current asthma therapies. Curr Drug Targets . 2006;7:525–540. - PubMed
1. Jiang S, Tang DD. Plk1 regulates MEK1/2 and proliferation in airway smooth muscle cells. Respir Res . 2015;16:93. - PMC - PubMed