COVID-19 and CAR T cells: a report on current challenges and future directions from the EPICOVIDEHA survey by EHA-IDWP

Alessandro Busca¹, Jon Salmanton-García^{2

3}, Paolo Corradini⁴, Francesco Marchesi⁵, Alba Cabirta^{6

7}, Roberta Di Blasi⁸, Remy Dulery⁹, Sylvain Lamure¹⁰, Francesca Farina¹¹, Barbora Weinbergerová¹², Josip Batinić^{13

14

15}, Anna Nordlander¹⁶, Alberto López-García¹⁷, Ľuboš Drgoňa¹⁸, Ildefonso Espigado-Tocino¹⁹, Iker Falces-Romero²⁰, Ramón García-Sanz²¹, Carolina García-Vidal²², Anna Guidetti²³, Nina Khanna²⁴, Austin Kulasekararaj²⁵, Johan Maertens²⁶, Martin Hoenigl^{27

28

29}, Nikolai Klimko³⁰, Philipp Koehler^{2

3}, Antonio Pagliuca³¹, Francesco Passamonti³², Oliver A Cornely^{2

3

33

34}, Livio Pagano^{35

36}

Affiliations

¹ Stem Cell Transplant Center, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Turin, Italy.
² Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
³ Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University Hospital Cologne, Cologne, Germany.
⁴ University of Milan and Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy.
⁵ Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
⁶ Department of Hematology, Vall d'Hebron Hospital Universitari, Vall d'Hebron Istitute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
⁷ Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.
⁸ Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
⁹ Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, AP-HP, Unité Mixte de Recherche (UMR) 938, Sorbonne Universitè, Paris, France.
¹⁰ Department of Clinical Hematology, Montpellier University Hospital, IGMM UMR1535 CNRS, University of Montpellier, Montpellier, France.
¹¹ IRCCS Ospedale San Raffaele, Milan, Italy.
¹² Department of Internal Medicine-Hematology and Oncology, Masaryk University Hospital Brno, Brno, Czech Republic.
¹³ University Hospital Centre Zagreb, Zagreb, Croatia.
¹⁴ Croatian Cooperative Group for Hematological Diseases (CROHEM), Zagreb, Croatia.
¹⁵ Faculty of Medicine, University of Zagreb, Zagreb, Croatia.
¹⁶ Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
¹⁷ Fundacion Jimenez-Díaz, Madrid, Spain.
¹⁸ Comenius University and National Cancer Institute, Bratislava, Slovakia.
¹⁹ Hospital Univesitario Virgen del Rocío, Seville, Spain.
²⁰ La Paz University Hospital, Madrid, Spain.
²¹ Hospital Universitario de Salamanca, Salamanca, Spain.
²² Hospital Clinic, Barcelona, Spain.
²³ Division of Hematology and Bone Marrow Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Milano, Milan, Italy.
²⁴ Division of Infectious Diseases and Hospital Epidemiology, Department of Clinical Research, University and University Hospital of Basel, Basel, Switzerland.
²⁵ King's College Hospital, London, United Kingdom.
²⁶ Katholieke Universiteit Leuven, Leuven, Belgium.
²⁷ Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, CA.
²⁸ Clinical and Translational Fungal Working Group, University of California San Diego, La Jolla, CA.
²⁹ Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
³⁰ Department of Clinical Mycology, Allergy and Immunology, North Western State Medical University, St Petersburg, Russia.
³¹ Department of Hematological Medicine, Kings College Hospital, National Health Service Foundation Trust, London, United Kingdom.
³² Department of Medicine and Surgery, University of Insubria and Azienda Socio Sanitaria Territoriale Sette Laghi, Ospedale di Circolo of Varese, Varese, Italy.
³³ University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne, Cologne, Germany.
³⁴ German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany.
³⁵ Hematology, IRCCS Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy; and.
³⁶ Hematology, Università Cattolica del Sacro Cuore, Rome, Italy.

PMID: 34749396
PMCID: PMC8575532
DOI: 10.1182/bloodadvances.2021005616

COVID-19 and CAR T cells: a report on current challenges and future directions from the EPICOVIDEHA survey by EHA-IDWP

Alessandro Busca et al. Blood Adv. 2022.

. 2022 Apr 12;6(7):2427-2433.

doi: 10.1182/bloodadvances.2021005616.

Authors

Affiliations

¹ Stem Cell Transplant Center, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Turin, Italy.
² Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
³ Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University Hospital Cologne, Cologne, Germany.
⁴ University of Milan and Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy.
⁵ Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
⁶ Department of Hematology, Vall d'Hebron Hospital Universitari, Vall d'Hebron Istitute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
⁷ Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.
⁸ Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
⁹ Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, AP-HP, Unité Mixte de Recherche (UMR) 938, Sorbonne Universitè, Paris, France.
¹⁰ Department of Clinical Hematology, Montpellier University Hospital, IGMM UMR1535 CNRS, University of Montpellier, Montpellier, France.
¹¹ IRCCS Ospedale San Raffaele, Milan, Italy.
¹² Department of Internal Medicine-Hematology and Oncology, Masaryk University Hospital Brno, Brno, Czech Republic.
¹³ University Hospital Centre Zagreb, Zagreb, Croatia.
¹⁴ Croatian Cooperative Group for Hematological Diseases (CROHEM), Zagreb, Croatia.
¹⁵ Faculty of Medicine, University of Zagreb, Zagreb, Croatia.
¹⁶ Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
¹⁷ Fundacion Jimenez-Díaz, Madrid, Spain.
¹⁸ Comenius University and National Cancer Institute, Bratislava, Slovakia.
¹⁹ Hospital Univesitario Virgen del Rocío, Seville, Spain.
²⁰ La Paz University Hospital, Madrid, Spain.
²¹ Hospital Universitario de Salamanca, Salamanca, Spain.
²² Hospital Clinic, Barcelona, Spain.
²³ Division of Hematology and Bone Marrow Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Milano, Milan, Italy.
²⁴ Division of Infectious Diseases and Hospital Epidemiology, Department of Clinical Research, University and University Hospital of Basel, Basel, Switzerland.
²⁵ King's College Hospital, London, United Kingdom.
²⁶ Katholieke Universiteit Leuven, Leuven, Belgium.
²⁷ Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, CA.
²⁸ Clinical and Translational Fungal Working Group, University of California San Diego, La Jolla, CA.
²⁹ Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
³⁰ Department of Clinical Mycology, Allergy and Immunology, North Western State Medical University, St Petersburg, Russia.
³¹ Department of Hematological Medicine, Kings College Hospital, National Health Service Foundation Trust, London, United Kingdom.
³² Department of Medicine and Surgery, University of Insubria and Azienda Socio Sanitaria Territoriale Sette Laghi, Ospedale di Circolo of Varese, Varese, Italy.
³³ University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne, Cologne, Germany.
³⁴ German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany.
³⁵ Hematology, IRCCS Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy; and.
³⁶ Hematology, Università Cattolica del Sacro Cuore, Rome, Italy.

PMID: 34749396
PMCID: PMC8575532
DOI: 10.1182/bloodadvances.2021005616

Abstract

The EHA-IDWP developed an observational registry collecting data on COVID-19 infection in patients who received CAR T-cell therapy.
Prevalence of COVID-19 was 4.8%, and overall mortality was 50%, highlighting the need for prevention of infection in these patients.

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References

1. Guan WJ, Ni ZY, Hu Y, et al. ; China Medical Treatment Expert Group for Covid-19 . Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. - PMC - PubMed
1. Miyashita H, Mikami T, Chopra N, et al. Do patients with cancer have a poorer prognosis of COVID-19? An experience in New York City. Ann Oncol. 2020;31(8):1088-1089. - PMC - PubMed
1. Passamonti F, Cattaneo C, Arcaini L, et al. Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study. Lancet Haematol. 2020;7(10):e737-e745. - PMC - PubMed
1. Mehta V, Goel S, Kabarriti R, et al. Case fatality rate of cancer patients with COVID-19 in a New York hospital system. Cancer Discov. 2020; 10(7):935-941. - PMC - PubMed
1. Malard F, Genthon A, Brissot E, et al. COVID-19 outcomes in patients with hematologic disease. Bone Marrow Transplant. 2020;55(11):2180-2184. - PMC - PubMed

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COVID-19 and CAR T cells: a report on current challenges and future directions from the EPICOVIDEHA survey by EHA-IDWP

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COVID-19 and CAR T cells: a report on current challenges and future directions from the EPICOVIDEHA survey by EHA-IDWP

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