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. 1987:496:151-7.
doi: 10.1111/j.1749-6632.1987.tb35758.x.

Concentration-dependent effect of met-enkephalin on human polymorphonuclear leukocytes

G Fóris, G A Medgyesi, J T Nagy, Z Varga

Concentration-dependent effect of met-enkephalin on human polymorphonuclear leukocytes

G Fóris et al. Ann N Y Acad Sci. 1987.

Abstract

Met-enkephalin in 10(-9)-10(-7)M concentrations exerts an ADCC-stimulating effect on human PMNLs through naloxone-sensitive opiate receptors, elevating the cytoplasmic free Ca2+ and cGMP levels. In higher, 10(-6)-10(-5)M concentrations ME has a cAMP-elevating effect and a rapid 45Ca2+ influx was observed. This latter effect of ME, which is also associated with the suppression of ADCC activity, was abolished by the enkephalinase inhibitor, puromycin. A strong relationship is suggested between the suppressing effect of metenkephalin, enkaphalinase and the protein kinase C system.

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