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. 2022 Jan;40(1):1-3.
doi: 10.1016/j.urolonc.2021.09.022. Epub 2021 Nov 5.

Critical shortage in BCG immunotherapy: How did we get here and where will it take us?

Michael Harvey  1 , Bodie Chislett  2 , Marlon Perera  3 , Nathan Lawrentschuk  4 , Damien Bolton  2 , Gregory Jack  2
Affiliations

Critical shortage in BCG immunotherapy: How did we get here and where will it take us?

Michael Harvey et al. Urol Oncol. 2022 Jan.

Abstract

Intravesical Bacillus Calmette-Guérin vaccine, one of the most successful bio-therapies to date, has been the gold standard treatment for non-muscle invasive bladder cancer for 44 years. International shortages have necessitated rationing this life-saving medication with deleterious effects on the primary treatment of high-grade non-muscle invasive bladder cancer. Understanding the history of intravesical Bacillus Calmette-Guérin gives us insight into the current shortages and future perspectives for novel immunotherapy opportunities against this deadly disease.

Keywords: Bacillus Calmette-Guérin vaccine; Bladder cancer; Immunotherapy; Tuberculosis.

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