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. 2022 May;21(5):687-694.
doi: 10.1007/s43630-021-00126-7. Epub 2021 Nov 9.

Photochemical C-H acetalization of O-heterocycles utilizing phenylglyoxylic acid as the photoinitiator

Giorgos S Koutoulogenis  1 , Nikoleta Spiliopoulou  1 , Christoforos G Kokotos  2
Affiliations

Photochemical C-H acetalization of O-heterocycles utilizing phenylglyoxylic acid as the photoinitiator

Giorgos S Koutoulogenis et al. Photochem Photobiol Sci. 2022 May.

Abstract

A novel, mild, metal-free and easy-to-execute procedure for the C-H acetalization of O-heterocycles via visible light activation is presented, utilizing phenylglyoxylic acid as the photoinitiator. Biomass-derived O-heterocycles, like THF, can be employed, while primary, secondary alcohols and alcohols bearing a variety of functionalities were succesfully employed, affording the desired acetals in high yields. Facile acidic deprotection was also performed.

Keywords: Phenylglyoxylic acid; Photochemical C–H acetalization; Photoinitiator; Photoorganocatalysis.

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