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. 2021 Nov 9:10:e72185.
doi: 10.7554/eLife.72185.

Consensus-based guidance for conducting and reporting multi-analyst studies

Affiliations

Consensus-based guidance for conducting and reporting multi-analyst studies

Balazs Aczel et al. Elife. .

Abstract

Any large dataset can be analyzed in a number of ways, and it is possible that the use of different analysis strategies will lead to different results and conclusions. One way to assess whether the results obtained depend on the analysis strategy chosen is to employ multiple analysts and leave each of them free to follow their own approach. Here, we present consensus-based guidance for conducting and reporting such multi-analyst studies, and we discuss how broader adoption of the multi-analyst approach has the potential to strengthen the robustness of results and conclusions obtained from analyses of datasets in basic and applied research.

Keywords: analytical variability; expert consensus; medicine; metascience; multi-analyst; neuroscience; none; science forum; statistical practice.

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Conflict of interest statement

BA, BS, GN, Ov, CA, Mv, JB, DB, UB, RB, LB, NB, EC, AC, NC, AD, Nv, CD, Jv, AD, GD, GE, MG, RH, SH, FH, JH, MJ, KJ, AK, MK, YK, DL, JM, DM, MM, BN, RP, Dv, JR, MS, AS, TS, MS, DS, RS, DS, BS, SS, JS, EU, JW, EW No competing interests declared, BN Executive Director of the Center for Open Science, a non-profit technology and culture change organization with a mission to increase openness, integrity, and reproducibility of research

Figures

Figure 1.
Figure 1.. Analysis choices and alternative plausible paths.
The analysis of a large dataset can involve a sequence of analysis choices, as depicted in these schematic diagrams. The analyst first must decide between two options at the start of the analysis (top), and must make three additional decisions during the analysis: this leads to 16 possible paths for the analysis (grey lines). The left panel shows an example in which all possible paths lead to the same conclusion; the right panel shows an example in which some paths lead to conclusion A and other paths lead to conclusion B. Unless we can test alternative paths, we cannot know if the results obtained by following one particular path (thick black line) are robust, or if other plausible paths would lead to different results.

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