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. 2022 Jan-Mar;44(1):1-6.
doi: 10.1016/j.htct.2021.07.008. Epub 2021 Nov 4.

Antibody response against SARS-CoV-2 in convalescent plasma donors: Can we predict subjects' eligibility?

Tiago Paiva Prudente  1 , Renato Gomes Castro  2 , Marcos Antonio Candido  2 , Roberta Luiza Rodrigues  2 , Layane Marques de Souza  3 , Maria do Rosario Ferraz Roberti  4
Affiliations

Antibody response against SARS-CoV-2 in convalescent plasma donors: Can we predict subjects' eligibility?

Tiago Paiva Prudente et al. Hematol Transfus Cell Ther. 2022 Jan-Mar.

Abstract

Introduction: As the Coronavirus Disease 2019 (COVID-19) pandemic unfolds around the world; answers related to the antibody response against the virus are necessary to develop treatment and prophylactic strategies. We attempted to understand part of the immune response of convalescent plasma donation candidates.

Method: We carried out a cross-sectional, observational, non-intervention study, testing 102 convalescent plasma donation candidates for antibodies against the virus, relating these data to the time interval between symptom onset and sample collection, age, disease severity, and gender.

Results: In our sample, the individuals who developed a greater antibody response were the ones who had a longer time interval between symptom onset and sample collection, the ones who had been hospitalized and the subjects above 35 years old. Moreover, 17 individuals did not present any reactive antibodies.

Conclusion: These results are important in that they raise questions about the role of the humoral response against the virus, as some individuals do not develop antibodies to fight it. In addition, they help develop recruitment strategies for convalescent plasma donors, who should be asymptomatic for at least 21 days and are possibly more likely to have reactive antibodies after 35 days without symptoms.

Keywords: Blood donation; COVID-19 convalescent plasma treatment; COVID-19 serological testing; Coronavirus infections.

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Conflict of interest statement

None.

Figures

Fig. 1
Figure 1
Comparison between the antibody response and the severity of the disease (1A, according to IgM, and 1B, according to IgG).
Fig. 2
Figure 2
Comparison between the antibody response and age.
See this image and copyright information in PMC

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