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. 1987 Jul;116(3):465-8.
doi: 10.1093/genetics/116.3.465.

Linkage of the steroid sulfatase gene to the sex-reversed mutation in the mouse

E A Keitges, D F Schorderet, S M Gartler

Linkage of the steroid sulfatase gene to the sex-reversed mutation in the mouse

E A Keitges et al. Genetics. 1987 Jul.

Abstract

Dosage studies and the inheritance pattern of the gene for steroid sulfatase (Sts) in the mouse have previously provided indirect evidence for a functional Y-linked allele which recombines obligatorily with its X-linked allele in male meiosis. In this study, we have investigated the linkage relationship of Sts and the sex-reversed mutation (Sxr), a gene which is known to reside in the pairing region of the Y chromosome. The results clearly demonstrate that Sxr and Sts are linked in a region of obligatory recombination and Sts maps proximal to Sxr with most recombinants occurring proximal to the two genes.

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