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Comment
. 2021 Nov 8;39(11):1458-1460.
doi: 10.1016/j.ccell.2021.10.004. Epub 2021 Nov 8.

Capitalizing on the messenger: Intra-tumoral delivery of RNA with a systemic effect

Patrick A Ott  1
Affiliations
Comment

Capitalizing on the messenger: Intra-tumoral delivery of RNA with a systemic effect

Patrick A Ott. Cancer Cell. .

Abstract

As reported recently in Science Translational Medicine, intra-tumoral administration of mRNAs that encode four cytokines formulated in saline mediates regression of injected and distant murine tumors. The anti-tumor effect, which is also seen in the anti-PD-1-resistant setting and enhanced by checkpoint blockade, is mediated by tumor-specific T cells and natural killer cells.

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Conflict of interest statement

Declaration of interests Patrick A. Ott has received research funding from and/or has advised Neon Therapeutics, Bristol-Meyers Squibb, Merck, CytomX, Pfizer, Novartis, Celldex, Oncorus, Xencor, Amgen, Array, AstraZeneca/MedImmune, Armo BioSciences, and Roche/Genentech.

Figures

Figure 1:
Figure 1:
Injection of murine tumors with RNAs encoding 4 cytokines leads to in vivo translation and induction of a local and systemic tumor-specific immune response, mediating regression of both injected and distant tumors. Immune responses are comprised of several immune cell populations including T cells, dendritic cells (DCs), and Natural Killer (NK) cells. Anti-tumor activity is dependent on the IFN-γ pathway, consistent with a key role for IL-12sc in the cytokine mixture, and tumor antigen-specific T cells are expanded intratumorally.
See this image and copyright information in PMC

Comment on

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