Do B-1 cells play a role in response to Mycobacterium tuberculosis Beijing lineages?
- PMID: 34753390
- PMCID: PMC8741279
- DOI: 10.1080/21505594.2021.2003116
Do B-1 cells play a role in response to Mycobacterium tuberculosis Beijing lineages?
Abstract
We highlight the need to include an analysis of the B-1 B cell subset to complement the characterization of the cell-mediated immune response to the Mycobacterium tuberculosis Beijing lineage. The literature describes the B-1 cell repertoire's involvement in the cell-mediated response within granulomas, which is different from the classic antibody response B cells are generally associated with. Specifically, the B-1 B cell subset migrates from other compartments along with other cells to the infection site. We provide details to complement the reported results from Cerezo-Cortes et al.
Keywords: B-1 B cell; Beijing lineage; cell mediated immunity; immune response; tuberculosis.
Conflict of interest statement
No potential conflict of interest was reported by the author(s).
Comment on
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Profiling the immune response to Mycobacterium tuberculosis Beijing family infection: a perspective from the transcriptome.Virulence. 2021 Dec;12(1):1689-1704. doi: 10.1080/21505594.2021.1936432. Virulence. 2021. PMID: 34228582 Free PMC article.
References
-
- Ribeiro SC, Gomes LL, Amaral EP, et al. Mycobacterium tuberculosis strains of the modern sublineage of the Beijing family are more likely to display increased virulence than strains of the ancient sublineage. J Clin Microbiol. 2014. Jul;52(7):2615–2624. PubMed PMID: 24829250; PubMed Central PMCID: PMCPMC4097719. - PMC - PubMed
-
- Borrell S, Gagneux S.. Infectiousness, reproductive fitness and evolution of drug-resistant Mycobacterium tuberculosis. Int J Tuberc Lung Dis. 2009. Dec;13(12):1456–1466. PubMed PMID: 19919762. - PubMed
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