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. 2022 May 1;106(5):938-949.
doi: 10.1097/TP.0000000000003973. Epub 2021 Nov 9.

The Need to Update Endpoints and Outcome Analysis in the Rapidly Changing Field of Liver Transplantation

Margot Fodor  1 , Heinz Zoller  2 , Rupert Oberhuber  1 , Robert Sucher  3 , Daniel Seehofer  3 , Umberto Cillo  4 , Pal Dag Line  5   6 , Herbert Tilg  2 , Stefan Schneeberger  1
Affiliations

The Need to Update Endpoints and Outcome Analysis in the Rapidly Changing Field of Liver Transplantation

Margot Fodor et al. Transplantation. .

Abstract

Liver transplantation (LT) survival rates have continued to improve over the last decades, mostly due to the reduction of mortality early after transplantation. The advancement is facilitating a liberalization of access to LT, with more patients with higher risk profiles being added to the waiting list. At the same time, the persisting organ shortage fosters strategies to rescue organs of high-risk donors. This is facilitated by novel technologies such as machine perfusion. Owing to these developments, reconsideration of the current and emerging endpoints for the assessment of the efficacy of existing and new therapies is warranted. While conventional early endpoints in LT have focused on the damage induced to the parenchyma, the fate of the bile duct and the recurrence of the underlying disease have a stronger impact on the long-term outcome. In light of this evolving landscape, we here attempt to reflect on the appropriateness of the currently used endpoints in the field of LT trials.

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Conflict of interest statement

The authors declare no funding or conflicts of interest.

References

    1. Adam R, Karam V, Cailliez V, et al.; all the other 126 contributing centers ( www.eltr.org ) and the European Liver and Intestine Transplant Association (ELITA). 2018 Annual Report of the European Liver Transplant Registry (ELTR)—50-year evolution of liver transplantation. Transpl Int. 2018;31:1293–1317.
    1. Younossi ZM, Stepanova M, Ong J, et al. Nonalcoholic steatohepatitis is the most rapidly increasing indication for liver transplantation in the United States. Clin Gastroenterol Hepatol. 2021;19:580–589.e5.
    1. Alqahtani SA, Broering DC, Alghamdi SA, et al. Changing trends in liver transplantation indications in Saudi Arabia: from hepatitis C virus infection to nonalcoholic fatty liver disease. BMC Gastroenterol. 2021;21:245.
    1. Haldar D, Kern B, Hodson J, et al.; European Liver and Intestine Transplant Association (ELITA). Outcomes of liver transplantation for nonalcoholic steatohepatitis: a European Liver Transplant Registry study. J Hepatol. 2019;71:313–322.
    1. Adam R, Karam V, Delvart V, et al.; All contributing centers ( www.eltr.org ); European Liver and Intestine Transplant Association (ELITA). Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR). J Hepatol. 2012;57:675–688.

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