Diet and depression: future needs to unlock the potential

Wolfgang Marx¹, Melissa M Lane², Meghan Hockey², Hajara Aslam², Ken Walder³, Alessandra Borsini⁴, Joseph Firth^{5

6}, Carmine M Pariante⁴, Kirsten Berding⁷, John F Cryan^{7

8}, Gerard Clarke^{7

9

10}, Jeffrey M Craig³, Kuan-Pin Su^{11

12

13}, David Mischoulon^{14

15}, Fernando Gomez-Pinilla¹⁶, Jane A Foster¹⁷, Patrice D Cani¹⁸, Sandrine Thuret¹⁹, Heidi M Staudacher², Almudena Sánchez-Villegas^{20

21}, Husnain Arshad²², Tasnime Akbaraly^{22

23}, Adrienne O'Neil², Felice N Jacka^{2

24

25

26}

Affiliations

¹ IMPACT (The Institute for Mental and Physical Health and Clinical Translation), Food and Mood Centre, Deakin University, Geelong, VIC, Australia. wolf.marx@deakin.edu.au.
² IMPACT (The Institute for Mental and Physical Health and Clinical Translation), Food and Mood Centre, Deakin University, Geelong, VIC, Australia.
³ IMPACT (The Institute for Mental and Physical Health and Clinical Translation), Metabolic Research Unit, Deakin University, Geelong, VIC, Australia.
⁴ Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
⁵ Division of Psychology and Mental Health, University of Manchester, Manchester, UK.
⁶ NICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia.
⁷ APC Microbiome Ireland, University College Cork, Cork, Ireland.
⁸ Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
⁹ Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland.
¹⁰ INFANT Research Centre, University College Cork, Cork, Ireland.
¹¹ Departments of Psychiatry and Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.
¹² An-Nan Hospital, China Medical University, Tainan, Taiwan.
¹³ College of Medicine, China Medical University, Taichung, Taiwan.
¹⁴ Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
¹⁵ Harvard Medical School, Boston, MA, USA.
¹⁶ Departments of Neurosurgery and Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
¹⁷ Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
¹⁸ WELBIO- Walloon Excellence in Life Sciences and BIOtechnology, Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, Brussels, Belgium.
¹⁹ Basic and Clinical Neuroscience Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
²⁰ Nutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain.
²¹ Biomedical Research Center Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
²² Université Paris-Saclay, UVSQ, Inserm, CESP, "DevPsy", 94807, Villejuif, France.
²³ Department of Epidemiology and Public Health, University College London, London, UK.
²⁴ Centre for Adolescent Health, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
²⁵ Black Dog Institute, Sydney, NSW, Australia.
²⁶ James Cook University, Townsville, QLD, Australia.

PMID: 34754110
DOI: 10.1038/s41380-021-01360-2

Free article

Comment

Diet and depression: future needs to unlock the potential

Wolfgang Marx et al. Mol Psychiatry. 2022 Feb.

Free article

. 2022 Feb;27(2):778-780.

doi: 10.1038/s41380-021-01360-2. Epub 2021 Nov 9.

Authors

Affiliations

¹ IMPACT (The Institute for Mental and Physical Health and Clinical Translation), Food and Mood Centre, Deakin University, Geelong, VIC, Australia. wolf.marx@deakin.edu.au.
² IMPACT (The Institute for Mental and Physical Health and Clinical Translation), Food and Mood Centre, Deakin University, Geelong, VIC, Australia.
³ IMPACT (The Institute for Mental and Physical Health and Clinical Translation), Metabolic Research Unit, Deakin University, Geelong, VIC, Australia.
⁴ Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
⁵ Division of Psychology and Mental Health, University of Manchester, Manchester, UK.
⁶ NICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia.
⁷ APC Microbiome Ireland, University College Cork, Cork, Ireland.
⁸ Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
⁹ Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland.
¹⁰ INFANT Research Centre, University College Cork, Cork, Ireland.
¹¹ Departments of Psychiatry and Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.
¹² An-Nan Hospital, China Medical University, Tainan, Taiwan.
¹³ College of Medicine, China Medical University, Taichung, Taiwan.
¹⁴ Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
¹⁵ Harvard Medical School, Boston, MA, USA.
¹⁶ Departments of Neurosurgery and Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
¹⁷ Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
¹⁸ WELBIO- Walloon Excellence in Life Sciences and BIOtechnology, Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, Brussels, Belgium.
¹⁹ Basic and Clinical Neuroscience Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
²⁰ Nutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain.
²¹ Biomedical Research Center Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
²² Université Paris-Saclay, UVSQ, Inserm, CESP, "DevPsy", 94807, Villejuif, France.
²³ Department of Epidemiology and Public Health, University College London, London, UK.
²⁴ Centre for Adolescent Health, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
²⁵ Black Dog Institute, Sydney, NSW, Australia.
²⁶ James Cook University, Townsville, QLD, Australia.

PMID: 34754110
DOI: 10.1038/s41380-021-01360-2

No abstract available

PubMed Disclaimer

Comment on

Diet and depression: exploring the biological mechanisms of action.
Marx W, Lane M, Hockey M, Aslam H, Berk M, Walder K, Borsini A, Firth J, Pariante CM, Berding K, Cryan JF, Clarke G, Craig JM, Su KP, Mischoulon D, Gomez-Pinilla F, Foster JA, Cani PD, Thuret S, Staudacher HM, Sánchez-Villegas A, Arshad H, Akbaraly T, O'Neil A, Segasby T, Jacka FN. Marx W, et al. Mol Psychiatry. 2021 Jan;26(1):134-150. doi: 10.1038/s41380-020-00925-x. Epub 2020 Nov 3. Mol Psychiatry. 2021. PMID: 33144709 Review.
There is not much to mediate [yet] when it comes to diet and depression.
Molendijk ML, Molero P, Thomas-Odenthal F, van der Does W. Molendijk ML, et al. Mol Psychiatry. 2022 Feb;27(2):776-777. doi: 10.1038/s41380-021-01382-w. Epub 2021 Nov 9. Mol Psychiatry. 2022. PMID: 34754109 No abstract available.

References

1. Jacka FN, O’Neil A, Itsiopoulos C, Opie R, Cotton S, Mohebbi M, et al. The SMILES trial: an important first step. BMC Med. 2018;16:1–3. - DOI
1. Nicolaou M, Colpo M, Vermeulen E, Elstgeest LE, Cabout M, Gibson-Smith D, et al. Association of a priori dietary patterns with depressive symptoms: a harmonised meta-analysis of observational studies. Psychol Med. 2020;50:1872–83. - DOI
1. Firth J, Marx W, Dash S, Carney R, Teasdale SB, Solmi M, et al. The effects of dietary improvement on symptoms of depression and anxiety: a meta-analysis of randomized controlled trials. Psychosom Med. 2019;81:265. - DOI
1. Jacka FN, O’Neil A, Opie R, Itsiopoulos C, Cotton S, Mohebbi M, et al. A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’trial). BMC Med. 2017;15:1–13. - DOI
1. Parletta N, Zarnowiecki D, Cho J, Wilson A, Bogomolova S, Villani A, et al. A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: a randomized controlled trial (HELFIMED). Nutritional Neurosci. 2019;22:474–87. - DOI

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Diet and depression: future needs to unlock the potential

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Diet and depression: future needs to unlock the potential

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