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. 2021 Nov 2:14:7567-7578.
doi: 10.2147/IJGM.S329604. eCollection 2021.

Prevalence and Associated Factors of Kidney Dysfunction in Patients with Hypertension and/or Diabetes Mellitus from a Primary Care Population in Northwest China

Mengyue Lin  1   2 , Mulalibieke Heizhati  2 , Lin Wang  2 , Lin Gan  1   2 , Mei Li  2 , Wenbo Yang  2 , Ling Yao  2 , Zhongrong Wang  2 , Zhikang Yang  2 , Reyila Abudoyreyimu  2 , Zihao Wu  2 , Nanfang Li  1   2
Affiliations

Prevalence and Associated Factors of Kidney Dysfunction in Patients with Hypertension and/or Diabetes Mellitus from a Primary Care Population in Northwest China

Mengyue Lin et al. Int J Gen Med. .

Abstract

Purpose: The burden of kidney dysfunction (KD) is rapidly increasing in developing countries due to an ongoing epidemic of hypertension and diabetes. We aimed to evaluate the prevalence and associated factors of KD among population with hypertension and/or diabetes from primary care setting.

Methods: This study was part of a cross-sectional study conducted in Northwest China, which aimed to investigate the epidemiological status of hypertension and other chronic noninfectious diseases. Subjects aged ≥18 years old with hypertension and/or diabetes were included in this study. KD was defined as estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73m2. Least absolute shrinkage and selection operator and multivariable logistic regression were used to identify factors associated with KD. Sensitivity analysis was performed by comparing the results of different estimated equations for GFR.

Results: A total of 8899 participants with hypertension and/or diabetes were included. Prevalence of KD was 8.69% (n=144) among patients with both hypertension and DM, 3.36% (n=198) among patients with only hypertension, and 5.22% (n=70) among patients with only diabetes. Women showed higher prevalent KD than men. Modifiable factors independently associated with KD among patients with hypertension and/or diabetes included physical activity, duration of hypertension or DM, anemia, fasting plasma glucose and triglyceride. Results of different estimated equations showed similar trends of difference in the prevalence of KD among groups.

Conclusion: KD is common in patients with hypertension and/or DM in Northwest China. More attention should be paid to high-risk patients, especially to those with co-existence of hypertension and DM. Control of blood glucose and triglyceride may further improve KD management in this patient population.

Keywords: diabetes; epidemiology; hypertension; kidney dysfunction.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flow chart of screening and including subjects.
Figure 2
Figure 2
Prevalence of kidney dysfunction in patients with hypertension and/or diabetes based on MDRD equation. *Indicates P<0.01.
See this image and copyright information in PMC

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