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Case Reports
. 2021 Oct 27;6(2):31-36.
doi: 10.22551/2019.23.0602.10151. eCollection 2019.

Celiac disease: uncommon, oligosymptomatic course of illness, with profound hypoalbuminemia in an adult patient

Łukasz Lis  1 , Andrzej Konieczny  1 , Patryk Jerzak  1 , Paweł Podgórski  1 , Krzysztof Benc  1 , Zbigniew Hruby  1
Affiliations
Case Reports

Celiac disease: uncommon, oligosymptomatic course of illness, with profound hypoalbuminemia in an adult patient

Łukasz Lis et al. Arch Clin Cases. .

Abstract

Celiac disease (CD) is an immune-mediated disease, caused by gluten, occurring in people with genetic predisposition. The course of the disease can vary and includes both intestinal and extra-intestinal manifestations. Many patients are undiagnosed for many years and some of them, in particular with nonspecific symptoms or asymptomatic, might never be diagnosed. We present a rare case of a patient, who's first and practically the only symptom of the disease was a pathological fracture of the ribs. In addition, despite the lack of clinical symptoms of malabsorption syndrome, malnutrition and proteinuria, we observed profound hypoalbuminemia and hypoproteinemia. This case suggests that CD diagnostic should be undertaken in evaluation of every patient with osteoporotic fractures and hypoalbuminemia.

Keywords: autoimmune diseases; celiac disease; hypoalbuminemia.

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Conflict of interest statement

The authors declare that they have no competing interests. All the authors have read and accepted the manuscript.

Figures

Fig. 1
Fig. 1
Image of duodenum in UGI Endoscopy
Fig. 2 a
Fig. 2 a
Histopathological examination: Marsh IIIA stage lesions (HE, x10)
Fig. 2 b
Fig. 2 b
Histopathological examination: Marsh IIIA stage lesions (HE, x20)
See this image and copyright information in PMC

References

    1. Gujral N, Freeman HJ, Thomson AB. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol. 2012;18(42):6036–6059. - PMC - PubMed
    1. Leffler DA, Schuppan D. Update on serologic testing in celiac disease. Am J Gastroenterol. 2010;105(12):2520–2524. - PubMed
    1. Ludvigsson JF, Card TR, Kaukinen K, et al. Screening for celiac disease in the general population and in high-risk groups. United European Gastroenterol J. 2015;3(2):106–120. - PMC - PubMed
    1. Sharma M, Singh P, Agnihotri A, et al. Celiac disease: a disease with varied manifestations in adults and adolescents. J Dig Dis. 2013;14(10):518–525. - PubMed
    1. Pinto-Sanchez MI, Bercik P, Verdu EF, et al. Extraintestinal manifestations of celiac disease. Dig Dis. 2015;33(2):147–154. - PubMed

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